Hauptseite > Publikationsdatenbank > Modern high resolution NMR for the study of structure, dynamics and interactions of biological macromolecules > print

001     55024
005     20200423204418.0
024 7 _ |a 10.1524/zpch.2006.220.5.567
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024 7 _ |a 0942-9352
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041 _ _ |a eng
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100 1 _ |a Stangler, T.
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245 _ _ |a Modern high resolution NMR for the study of structure, dynamics and interactions of biological macromolecules
260 _ _ |c 2006
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300 _ _ |a 567 - 613
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440 _ 0 |a Zeitschrift für physikalische Chemie
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500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a High resolution liquid state nuclear magnetic resonance spectroscopy (NMR) is a powerful technique for in vitro studies of structure and dynamics of soluble biological macromolecules under physiological conditions. The unique combination of atomically resolved structural data with both local and global dynamic features covering the entire range of time scales from picoseconds to seconds makes NMR the method of choice in a very diverse and rapidly growing array of biochemical, biomedical, and pharmaceutical applications. After briefly introducing the basic principles of liquid state NMR we review recent methodological and instrumental advances in the field of biologically focused high resolution NMR, The main emphasis of the second part is on molecular interactions. Such interactions are fundamental for the function of proteins in living systems, e.g. for signal transduction. enzymatic catalysis, and immune defense. The tremendous opportunities of high resolution NMR in the identification and detailed characterization of the sites and modes of molecular interactions will be demonstrated.
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653 2 0 |2 Author
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700 1 _ |a Hartmann, R.
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700 1 _ |a Willbold, D.
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700 1 _ |a Koenig, B. W.
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773 _ _ |0 PERI:(DE-600)2020854-6
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856 7 _ |u http://dx.doi.org/10.1524/zpch.2006.220.5.567
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