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| 001 | 55895 | ||
| 005 | 20200423204427.0 | ||
| 024 | 7 | _ | |a pmid:17261081 |2 pmid |
| 024 | 7 | _ | |a 10.1515/BC.2007.020 |2 DOI |
| 024 | 7 | _ | |a WOS:000243978600006 |2 WOS |
| 024 | 7 | _ | |a 2128/18356 |2 Handle |
| 037 | _ | _ | |a PreJuSER-55895 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 540 |
| 084 | _ | _ | |2 WoS |a Biochemistry & Molecular Biology |
| 100 | 1 | _ | |a Hoffmann, S. |b 0 |u FZJ |0 P:(DE-Juel1)VDB630 |
| 245 | _ | _ | |a Nef protein of human immunodeficiency virus type 1 binds its own myristoylated N-terminus |
| 260 | _ | _ | |a Berlin [u.a.] |b de Gruyter |c 2007 |
| 300 | _ | _ | |a 181 - 183 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a Biological Chemistry |x 1431-6730 |0 9042 |v 388 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a HIV-1 Nef is a small protein (approx. 25 kDa) that is posttranslationally modified by myristoylation. To explain its complex activities, a 'Nef-cycle' is discussed, which postulates different molecular conformations of Nef. Using recombinant full-length non-myristoylated Nef and synthetic peptides, we demonstrate by fluorescence titration experiments that a peptide representing the myristoylated N-terminus of Nef is specifically bound by Nef. A non-myristoylated N-terminal fragment of Nef or a myristoylated control peptide does not bind to Nef. These results are the first direct experimental evidence of the existence of a myristate-binding pocket in Nef, a prerequisite of the postulated 'closed' Nef conformation. |
| 536 | _ | _ | |a Funktion und Dysfunktion des Nervensystems |c P33 |2 G:(DE-HGF) |0 G:(DE-Juel1)FUEK409 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Calorimetry: methods |
| 650 | _ | 2 | |2 MeSH |a Gene Products, nef: chemistry |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Myristic Acid: chemistry |
| 650 | _ | 2 | |2 MeSH |a Peptides: chemistry |
| 650 | _ | 2 | |2 MeSH |a Recombinant Proteins: chemistry |
| 650 | _ | 2 | |2 MeSH |a Spectrometry, Fluorescence |
| 650 | _ | 2 | |2 MeSH |a nef Gene Products, Human Immunodeficiency Virus |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Gene Products, nef |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Peptides |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Recombinant Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a nef Gene Products, Human Immunodeficiency Virus |
| 650 | _ | 7 | |0 544-63-8 |2 NLM Chemicals |a Myristic Acid |
| 650 | _ | 7 | |a J |2 WoSType |
| 653 | 2 | 0 | |2 Author |a fluorescence titration |
| 653 | 2 | 0 | |2 Author |a peptide binding |
| 653 | 2 | 0 | |2 Author |a protein conformation |
| 700 | 1 | _ | |a Jonas, E. |b 1 |u FZJ |0 P:(DE-Juel1)VDB20019 |
| 700 | 1 | _ | |a König, S. |b 2 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Preusser-Kunze, A. |b 3 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Willbold, D. |b 4 |u FZJ |0 P:(DE-Juel1)132029 |
| 773 | _ | _ | |a 10.1515/BC.2007.020 |g Vol. 388, p. 181 - 183 |p 181 - 183 |q 388<181 - 183 |0 PERI:(DE-600)1466062-3 |t Biological chemistry |v 388 |y 2007 |x 1431-6730 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1515/BC.2007.020 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/55895/files/%5BBiological%20Chemistry%5D%20Nef%20protein%20of%20human%20immunodeficiency%20virus%20type%201%20binds%20its%20own%20myristoylated%20N-terminus.pdf |y OpenAccess |
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| 914 | 1 | _ | |y 2007 |
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| 915 | _ | _ | |a JCR/ISI refereed |0 StatID:(DE-HGF)0010 |
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