| 001 | 56130 | ||
| 005 | 20240610120033.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:16773394 |
| 024 | 7 | _ | |2 DOI |a 10.1007/s00249-006-0076-4 |
| 024 | 7 | _ | |2 WOS |a WOS:000240899300005 |
| 037 | _ | _ | |a PreJuSER-56130 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 084 | _ | _ | |2 WoS |a Biophysics |
| 100 | 1 | _ | |a Papadopoulos, G. |b 0 |0 P:(DE-HGF)0 |
| 245 | _ | _ | |a Changes in the level of poly(Phe) synthesis in Escherichia coli ribosomes containing mutants of L4 ribosomal protein from Thermus thermophilus can be explained by structural changes in the peptidyltransferase center: a molecular dynamics simulation anal. |
| 260 | _ | _ | |a Berlin |b Springer |c 2006 |
| 300 | _ | _ | |a 675 - 683 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a European Biophysics Journal : with Biophysics Letters |x 0175-7571 |0 10441 |y 8 |v 35 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a Data from polyphenylalanine [poly(Phe)] synthesis determination in the presence and in the absence of erythromycin have been used in conjunction with Molecular Dynamics Simulation analysis, in order to localize the functional sites affected by mutations of Thermus thermophilus ribosomal protein L4 incorporated in Escherichia coli ribosomes. We observed that alterations in ribosome capability to synthesize poly(Phe) in the absence of erythromycin were mainly correlated to shifts of A2062 and C2612 of 23S rRNA, while in the presence of erythromycin they were correlated to shifts of A2060 and U2584 of 23S rRNA. Our results suggest a means of understanding the role of the extended loop of L4 ribosomal protein in ribosomal peptidyltransferase center. |
| 536 | _ | _ | |a Kondensierte Materie |c P54 |2 G:(DE-HGF) |0 G:(DE-Juel1)FUEK414 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Amino Acid Sequence |
| 650 | _ | 2 | |2 MeSH |a Anti-Bacterial Agents: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Erythromycin: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Escherichia coli: drug effects |
| 650 | _ | 2 | |2 MeSH |a Escherichia coli: genetics |
| 650 | _ | 2 | |2 MeSH |a Escherichia coli: metabolism |
| 650 | _ | 2 | |2 MeSH |a Models, Molecular |
| 650 | _ | 2 | |2 MeSH |a Molecular Sequence Data |
| 650 | _ | 2 | |2 MeSH |a Mutation |
| 650 | _ | 2 | |2 MeSH |a Nucleic Acid Conformation |
| 650 | _ | 2 | |2 MeSH |a Peptides: metabolism |
| 650 | _ | 2 | |2 MeSH |a Peptidyl Transferases: chemistry |
| 650 | _ | 2 | |2 MeSH |a Peptidyl Transferases: metabolism |
| 650 | _ | 2 | |2 MeSH |a Protein Conformation |
| 650 | _ | 2 | |2 MeSH |a RNA, Bacterial: genetics |
| 650 | _ | 2 | |2 MeSH |a RNA, Ribosomal, 23S: genetics |
| 650 | _ | 2 | |2 MeSH |a Ribosomal Proteins: chemistry |
| 650 | _ | 2 | |2 MeSH |a Ribosomal Proteins: genetics |
| 650 | _ | 2 | |2 MeSH |a Ribosomal Proteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Ribosomes: genetics |
| 650 | _ | 2 | |2 MeSH |a Ribosomes: metabolism |
| 650 | _ | 2 | |2 MeSH |a Thermus thermophilus: metabolism |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Anti-Bacterial Agents |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Peptides |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a RNA, Bacterial |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a RNA, Ribosomal, 23S |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Ribosomal Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a ribosomal protein L4 |
| 650 | _ | 7 | |0 114-07-8 |2 NLM Chemicals |a Erythromycin |
| 650 | _ | 7 | |0 30394-07-1 |2 NLM Chemicals |a polyphenylalanine |
| 650 | _ | 7 | |0 EC 2.3.2.12 |2 NLM Chemicals |a Peptidyl Transferases |
| 650 | _ | 7 | |a J |2 WoSType |
| 653 | 2 | 0 | |2 Author |a molecular dynamics |
| 653 | 2 | 0 | |2 Author |a ribosomal function |
| 653 | 2 | 0 | |2 Author |a erythromycin |
| 700 | 1 | _ | |a Grudinin, S. |b 1 |u FZJ |0 P:(DE-Juel1)VDB10417 |
| 700 | 1 | _ | |a Kalpaxis, D. |b 2 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Choli-Papadopoulou, T. |b 3 |0 P:(DE-HGF)0 |
| 773 | _ | _ | |a 10.1007/s00249-006-0076-4 |g Vol. 35, p. 675 - 683 |p 675 - 683 |q 35<675 - 683 |0 PERI:(DE-600)1398349-0 |t European biophysics journal |v 35 |y 2006 |x 0175-7571 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1007/s00249-006-0076-4 |
| 909 | C | O | |o oai:juser.fz-juelich.de:56130 |p VDB |
| 913 | 1 | _ | |k P54 |v Kondensierte Materie |l Kondensierte Materie |b Materie |z entfällt bis 2009 |0 G:(DE-Juel1)FUEK414 |x 0 |
| 914 | 1 | _ | |a Nachtrag |y 2006 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |k IFF-TH-II |l Theorie II |d 31.12.2006 |g IFF |0 I:(DE-Juel1)VDB31 |x 1 |
| 970 | _ | _ | |a VDB:(DE-Juel1)87881 |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a ConvertedRecord |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-2-20110106 |
| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-5-20200312 |
| 981 | _ | _ | |a I:(DE-Juel1)IAS-2-20090406 |
| 981 | _ | _ | |a I:(DE-Juel1)ICS-2-20110106 |
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