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000056233 084__ $$2WoS$$aBiochemistry & Molecular Biology
000056233 1001_ $$0P:(DE-Juel1)129343$$aKastenholz, B.$$b0$$uFZJ
000056233 245__ $$aNew hope for the diagnosis and   therapy of Alzheimer's disease
000056233 260__ $$aSchiphol$$bBentham Science Publ.$$c2007
000056233 300__ $$a389 - 393
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000056233 520__ $$aImproperly folded metal cofactor-containing proteins (e.g., copper chaperone for Superoxide dismutase, CCS) are believed to play a key role in several protein-misfolding diseases (e.g., Alzheimer's disease or Amyotrophic Lateral Sclerosis) because Under regular physiological conditions, metallochaperolles activate or stabilize the native conformation of important metalloproteins (e.g., superoxide dismutase) in certain Cellular processes. For an improved diagnosis and therapy of neurodegenerative diseases, new methodologies have to be developed that enable a well-defined differentiation between properly folded and inactive metalloproteins in clinical samples. In the literature it is reported that different high molecular mass metal-containing proteins were isolated in brain samples from Alzheimer's patients and in vegetables by using a 2-dimensional polyacrylamide gel electrophoresis (2-DE) procedure. In the present article, selected results of these studies are Scrutinized and compared with some results obtained by a standardized method termed 'quantitative preparative native continuous polycrylamide gel electrophoresis (QPNC-PAGE)'. Conclusively, QPNC-PAGE is a highly efficient approach used by biochemists to resolve native and denatured metalloproteins (MW 6 - >= 200 kDa) in complex protein Mixtures.
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000056233 65320 $$2Author$$aQPNC-PAGE
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000056233 65320 $$2Author$$aGPC
000056233 65320 $$2Author$$aNMR
000056233 65320 $$2Author$$aCCS
000056233 65320 $$2Author$$aAlzheimer's disease
000056233 65320 $$2Author$$aisoelectric point
000056233 65320 $$2Author$$anative conformation
000056233 65320 $$2Author$$abreakthrough method
000056233 65320 $$2Author$$abiofluids
000056233 65320 $$2Author$$acadmium protein
000056233 65320 $$2Author$$afolding
000056233 65320 $$2Author$$aArabidopsis
000056233 65320 $$2Author$$ametal cofactor
000056233 65320 $$2Author$$aget structure
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000056233 8567_ $$uhttp://dx.doi.org/10.2174/092986607780363970
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