TY  - JOUR
AU  - Papagiannopoulos, A.
AU  - Waigh, T. A.
AU  - Hardingham, T.
AU  - Heinrich, M.
TI  - Solution Structure and Dynamics of Cartilage Aggrecan
JO  - Biomacromolecules
VL  - 7
SN  - 1525-7797
CY  - Columbus, Ohio
PB  - American Chemical Soc.
M1  - PreJuSER-56804
SP  - 2162 - 2172
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - A versatile atom transfer radical polymerization (ATRP) method for polysaccharide grafting in homogeneous mild conditions without using protecting group chemistry is presented. Water/DMF mixtures with different compositions were used as the solvent. The "grafting-from" approach was used in order to prepare suitable pullulan and dextran ATRP macroinitiators with a well controlled degree of functionalization. Methacrylate and acrylamide monomers were grafted obtaining good control over the number, molecular weight and polydispersity of the grafted chains without homopolymer formation and polysaccharide degradation. The versatility of this method allowed us to prepare comblike derivatives with a wide range of properties (amphiphilic, ionic, and thermoresponsive) by simply changing the solvent composition and the catalyst. This could make possible the synthesis of new interesting biomaterials starting from a wide range of polysaccharides.
KW  - Carbohydrate Conformation
KW  - Free Radicals: chemistry
KW  - Hydrolysis
KW  - Kinetics
KW  - Magnetic Resonance Spectroscopy
KW  - Models, Chemical
KW  - Polysaccharides: chemical synthesis
KW  - Polysaccharides: chemistry
KW  - Spectroscopy, Fourier Transform Infrared
KW  - Temperature
KW  - Free Radicals (NLM Chemicals)
KW  - Polysaccharides (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:16827582
UR  - <Go to ISI:>//WOS:000238848800012
DO  - DOI:10.1021/bm0601373
UR  - https://juser.fz-juelich.de/record/56804
ER  -