TY  - JOUR
AU  - Heim, S.
AU  - Eickhoff, S. B.
AU  - Amunts, K.
TI  - Different roles of cytoarchitectonic BA44 and BA45 in phonological and semantic verbal fluency as revealed by dynamic causal modelling
JO  - NeuroImage
VL  - 48
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - PreJuSER-5705
SP  - 616 - 624
PY  - 2009
N1  - This Human Brain Project/Neuroinformatics research is funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health (KA). Further support by the Brain Imaging Center West (BMBF 01GO0204) is gratefully acknowledged. We thank N. Jon Shah for the support of the NMR group at the INB-3 during fMRI data acquisition, in particular Barbara Elghahwagi for her assistance with fMRI data recording. Moreover, we appreciate the support by the Cognitive Neurology group at the INB-3, in particular by Ralph Weidner, Shahram Mirzazade, and Marcus Wilms, with respect to the peripheral stimulation devices.
AB  - The interactions of left cytoarchitectonic BA 44 and BA 45 during semantic and phonological verbal fluency tasks were investigated using dynamic causal modelling (DCM). Three different models were tested, all of which featured BA 44 and BA 45 as top-down driven interconnected nodes projecting to the motor cortex as the final output region. Model #1 represents the hypothesis that BA 45 is involved in lexical retrieval including both semantic and phonological processes, while BA 44 supports other phonological processes. Model #2 reflects the notion of a clear-cut segregation of computational processes sustained by BA 44 (phonological processing) and BA 45 (semantic processing). Model #3 was based on the hypothesis that both BA 44 and BA 45 support semantic and phonological processing. When these models were compared against each other by Bayesian model selection, evidence emerged in favour of the first model, implying that BA 45 supports word retrieval processes whereas BA 44 is involved in processing phonological information during word generation. In a subsequent analysis of the derived model parameters for model #1, all connection strengths were significantly positive except for the inhibitory coupling between BA 44 and BA 45. This inhibition may reflect how the phonological analysis in BA 44 during word generation constrains lexical word retrieval in BA 45. To conclude, DCM provided additional insights into the roles of BA 44 and BA 45 during verbal fluency revealing the involvement of BA 45 in lexical retrieval and the relevance of BA 44 for phonological processing during word generation.
KW  - Adult
KW  - Bayes Theorem
KW  - Computer Simulation
KW  - Female
KW  - Frontal Lobe: physiology
KW  - Humans
KW  - Language
KW  - Language Tests
KW  - Linear Models
KW  - Linguistics
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Mental Processes: physiology
KW  - Models, Neurological
KW  - Motor Cortex: physiology
KW  - Neural Inhibition
KW  - Neural Pathways: physiology
KW  - Phonetics
KW  - Psychomotor Performance: physiology
KW  - Speech: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19560543
C2  - pmc:PMC2770255
UR  - <Go to ISI:>//WOS:000274724000014
DO  - DOI:10.1016/j.neuroimage.2009.06.044
UR  - https://juser.fz-juelich.de/record/5705
ER  -