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000057200 0247_ $$2DOI$$a10.1016/j.jmmm.2006.10.1164
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000057200 084__ $$2WoS$$aMaterials Science, Multidisciplinary
000057200 084__ $$2WoS$$aPhysics, Condensed Matter
000057200 1001_ $$0P:(DE-Juel1)128697$$aKrause, H.-J.$$b0$$uFZJ
000057200 245__ $$aMagnetic particle detection by frequency mixing for immunoassay applications
000057200 260__ $$aAmsterdam$$bNorth-Holland Publ. Co.$$c2007
000057200 300__ $$a436 - 444
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000057200 440_0 $$03490$$aJournal of Magnetism and Magnetic Materials$$v311$$x0304-8853
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000057200 520__ $$aFor magnetic immunoassay applications, a novel magnetic reader for quantification of magnetic particle concentrations has been developed. Upon magnetic excitation at two distinct frequencies incident on the sample, the response signal generated at a sum frequency is detected. The low-frequency field component periodically drives the magnetic particles into saturation, which is probed by the high-frequency field. The appearance of frequency mixing lines is highly specific to the nonlinearity of the superparamagnetic particles' magnetization. The optimization of field coils, differential pickup coil, preamplifier, demodulators and filters are discussed. The output signal is linear for four orders of magnitude in iron concentration. (C) 2006 Elsevier B.V. All rights reserved.
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000057200 65320 $$2Author$$amagnetic detection
000057200 65320 $$2Author$$afrequency mixing
000057200 65320 $$2Author$$asuperparamagnetism
000057200 65320 $$2Author$$anonlinearity
000057200 65320 $$2Author$$ainduction coil
000057200 65320 $$2Author$$aimmunoassay
000057200 7001_ $$0P:(DE-Juel1)VDB5403$$aWolters, N.$$b1$$uFZJ
000057200 7001_ $$0P:(DE-Juel1)VDB5476$$aZhang, Y.$$b2$$uFZJ
000057200 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, A.$$b3$$uFZJ
000057200 7001_ $$0P:(DE-HGF)0$$aMiethe, P.$$b4
000057200 7001_ $$0P:(DE-HGF)0$$aMeyer, M. H. F.$$b5
000057200 7001_ $$0P:(DE-HGF)0$$aHartmann, M.$$b6
000057200 7001_ $$0P:(DE-HGF)0$$aKeusgen, M.$$b7
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000057200 8567_ $$uhttp://dx.doi.org/10.1016/j.jmmm.2006.10.1164
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