TY  - JOUR
AU  - Giessing, C.
AU  - Thiel, C. M.
AU  - Rösler, F.
AU  - Fink, G. R.
TI  - The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability
JO  - Neuroscience
VL  - 137
SN  - 0306-4522
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-57851
SP  - 853 - 864
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - This functional magnetic resonance imaging study investigates the effects of nicotine in a cued target detection task when changing cue reliability. Fifteen non-smoking volunteers were studied under placebo and nicotine (Nicorette polacrilex gum 1 and 2 mg). Validly and invalidly cued trials were arranged in blocks with high, middle and low cue reliability. Two effects of nicotine were investigated: its influence on i) parietal cortex activity underlying the processing of invalid vs. valid trials (i.e. validity effect) and ii) neural activity in the context of low, middle and high informative value of the cue (i.e. cue reliability effect). Nicotine did not affect behavioral performance. However, nicotine reduced the difference in the blood oxygenation level dependent (BOLD) signal between invalid and valid trials in the right intraparietal sulcus. The reduction of parietal activity in invalid trials was smaller in the low cue reliability condition. The same posterior parietal region exhibited a nicotinic modulation of BOLD activity in valid trials which was dependent on cue reliability: Nicotine specifically enhanced the neural activity during valid trials in the context of low cue reliability, i.e. when subjects are already in a state of low certainty. We speculate that the right intraparietal sulcus might be part of two networks working in parallel: one responsible for reorienting attention and the other for the cholinergic modulation of cue reliability. By reducing the use of the cue, nicotine modulates parietal activity related to reorienting attention in conditions with higher cue certainty. On the other hand, nicotine increases parietal activity in states of low certainty. This enhanced activation might influence brain regions, such as the posterior cingulate, directly involved in the processing of cue reliability.
KW  - Adult
KW  - Attention: drug effects
KW  - Cues
KW  - Data Interpretation, Statistical
KW  - Dose-Response Relationship, Drug
KW  - Female
KW  - Functional Laterality: physiology
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Learning: drug effects
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Nicotine: pharmacology
KW  - Nicotinic Agonists: pharmacology
KW  - Oxygen: blood
KW  - Parietal Lobe: drug effects
KW  - Photic Stimulation
KW  - Psychomotor Performance: drug effects
KW  - Reaction Time: drug effects
KW  - Nicotinic Agonists (NLM Chemicals)
KW  - Nicotine (NLM Chemicals)
KW  - Oxygen (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:16309846
UR  - <Go to ISI:>//WOS:000235121000012
DO  - DOI:10.1016/j.neuroscience.2005.10.005
UR  - https://juser.fz-juelich.de/record/57851
ER  -