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@ARTICLE{Giessing:57851,
      author       = {Giessing, C. and Thiel, C. M. and Rösler, F. and Fink, G.
                      R.},
      title        = {{T}he modulatory effects of nicotine on parietal cortex
                      activity in a cued target detection task depend on cue
                      reliability},
      journal      = {Neuroscience},
      volume       = {137},
      issn         = {0306-4522},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-57851},
      pages        = {853 - 864},
      year         = {2006},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {This functional magnetic resonance imaging study
                      investigates the effects of nicotine in a cued target
                      detection task when changing cue reliability. Fifteen
                      non-smoking volunteers were studied under placebo and
                      nicotine (Nicorette polacrilex gum 1 and 2 mg). Validly and
                      invalidly cued trials were arranged in blocks with high,
                      middle and low cue reliability. Two effects of nicotine were
                      investigated: its influence on i) parietal cortex activity
                      underlying the processing of invalid vs. valid trials (i.e.
                      validity effect) and ii) neural activity in the context of
                      low, middle and high informative value of the cue (i.e. cue
                      reliability effect). Nicotine did not affect behavioral
                      performance. However, nicotine reduced the difference in the
                      blood oxygenation level dependent (BOLD) signal between
                      invalid and valid trials in the right intraparietal sulcus.
                      The reduction of parietal activity in invalid trials was
                      smaller in the low cue reliability condition. The same
                      posterior parietal region exhibited a nicotinic modulation
                      of BOLD activity in valid trials which was dependent on cue
                      reliability: Nicotine specifically enhanced the neural
                      activity during valid trials in the context of low cue
                      reliability, i.e. when subjects are already in a state of
                      low certainty. We speculate that the right intraparietal
                      sulcus might be part of two networks working in parallel:
                      one responsible for reorienting attention and the other for
                      the cholinergic modulation of cue reliability. By reducing
                      the use of the cue, nicotine modulates parietal activity
                      related to reorienting attention in conditions with higher
                      cue certainty. On the other hand, nicotine increases
                      parietal activity in states of low certainty. This enhanced
                      activation might influence brain regions, such as the
                      posterior cingulate, directly involved in the processing of
                      cue reliability.},
      keywords     = {Adult / Attention: drug effects / Cues / Data
                      Interpretation, Statistical / Dose-Response Relationship,
                      Drug / Female / Functional Laterality: physiology / Humans /
                      Image Processing, Computer-Assisted / Learning: drug effects
                      / Magnetic Resonance Imaging / Male / Nicotine: pharmacology
                      / Nicotinic Agonists: pharmacology / Oxygen: blood /
                      Parietal Lobe: drug effects / Photic Stimulation /
                      Psychomotor Performance: drug effects / Reaction Time: drug
                      effects / Nicotinic Agonists (NLM Chemicals) / Nicotine (NLM
                      Chemicals) / Oxygen (NLM Chemicals) / J (WoSType)},
      cin          = {IME},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB54},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:16309846},
      UT           = {WOS:000235121000012},
      doi          = {10.1016/j.neuroscience.2005.10.005},
      url          = {https://juser.fz-juelich.de/record/57851},
}