TY  - JOUR
AU  - Mamisch, T.Ch.
AU  - Menzel, M. I.
AU  - Welsch, G. H.
AU  - Bittersohl, B.
AU  - Salomonowitz, E.
AU  - Szomolanyi, P.
AU  - Kordelle, J.
AU  - Marlovits, St.
AU  - Trattnig, S.
TI  - Steady-state diffusion imaging for MR in-vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3 Tesla - preliminary results
JO  - European journal of radiology
VL  - 65
SN  - 0720-048x
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-58391
SP  - 72 - 79
PY  - 2008
N1  - Record converted from VDB: 12.11.2012
AB  - To demonstrate the feasibility of time-reversed fast imaging with steady-state precession (FISP) called PSIF for diffusion-weighted imaging of cartilage and cartilage transplants in a clinical study.In a cross-sectional study 15 patients underwent MRI using a 3D partially balanced steady-state gradient echo pulse sequence with and without diffusion weighting at two different time points after matrix-associated autologous cartilage transplantation (MACT). Mean diffusion quotients (signal intensity without diffusion-weighting divided by signal intensity with diffusion weighting) within the cartilage transplants were compared to diffusion quotients found in normal cartilage.The global diffusion quotient found in repair cartilage was significantly higher than diffusion values in normal cartilage (p<0.05). There was a decrease between the earlier and the later time point after surgery.In-vivo diffusion-weighted imaging based on the PSIF technique is possible. Our preliminary results show follow-up of cartilage transplant maturation in patients may provide additional information to morphological assessment.
KW  - Adult
KW  - Analysis of Variance
KW  - Cartilage, Articular: metabolism
KW  - Cartilage, Articular: pathology
KW  - Cell Transplantation: methods
KW  - Chondrocytes: transplantation
KW  - Cross-Sectional Studies
KW  - Diffusion Magnetic Resonance Imaging: methods
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Imaging, Three-Dimensional
KW  - Knee Joint: surgery
KW  - Male
KW  - Treatment Outcome
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:17977685
UR  - <Go to ISI:>//WOS:000253086400009
DO  - DOI:10.1016/j.ejrad.2007.09.015
UR  - https://juser.fz-juelich.de/record/58391
ER  -