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@ARTICLE{Merkel:58487,
      author       = {Merkel, R. and Kirchgeßner, N. and Cesa, C. M. and
                      Hoffmann, B.},
      title        = {{C}ell {F}orce {M}icroscopy on {E}lastic {L}ayers of
                      {F}inite {T}hickness},
      journal      = {Biophysical journal},
      volume       = {93},
      issn         = {0006-3495},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {PreJuSER-58487},
      pages        = {3314 - 3323},
      year         = {2007},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Forces applied by cells to substrates can be measured using
                      soft substrates with embedded displacement markers. Traction
                      forces are retrieved from microscopic images by determining
                      the displacements of these markers and fitting the
                      generating forces. Here we show that using elastic films of
                      5-10-microm thickness one can improve the spatial resolution
                      of the technique. To this end we derived explicit equations
                      for the mechanical response of an elastic layer of finite
                      thickness to point forces. Moreover, these equations allow
                      highly accurate force measurements on eukaryotic cells on
                      films where finite thickness effects are relevant (below
                      approximately 60 microm).},
      keywords     = {Animals / Elasticity / Fibroblasts: ultrastructure /
                      Microscopy, Atomic Force / Myocytes, Cardiac: ultrastructure
                      / Rats / Rats, Wistar / Silicon / Silicon (NLM Chemicals) /
                      J (WoSType)},
      cin          = {IBN-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB802},
      pnm          = {Kondensierte Materie},
      pid          = {G:(DE-Juel1)FUEK414},
      shelfmark    = {Biophysics},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17660320},
      pmc          = {pmc:PMC2025665},
      UT           = {WOS:000250199300036},
      doi          = {10.1529/biophysj.107.111328},
      url          = {https://juser.fz-juelich.de/record/58487},
}