TY  - JOUR
AU  - Gorshkova, Yu.E.
AU  - Gordeliy, V. I.
TI  - Investigation of Interaction of Dimethylsulfoxide with Lipid Membranes via Small-Angle Neutron Scattering
JO  - Crystallography reports
VL  - 52
SN  - 1063-7745
CY  - Woodbury, NY
PB  - MAIK "Nauka/Interperiodica"
M1  - PreJuSER-59134
SP  - 535 - 539
PY  - 2007
N1  - Record converted from VDB: 12.11.2012
AB  - The influence of dimethyl sulfoxide (CH3)(2)SO (DMSO) on the structure of membranes of 1,2-dimiristoyl-sn-glycero-3-phosphatidylcholine (DMPC) in an excess of a water-DMSO solvent is investigated over a wide range of DMSO molar concentrations 0.0 <= X-DMSO <= 1.0 at temperatures T = 12.5 and 55 degrees C. The dependences of the repeat distance d of multilamellar membranes and the thickness d(b) of single vesicles on the molar concentration X-DMSO in the L-beta. gel and L-alpha liquid-crystalline phases are determined by small-angle neutron scattering. The intermembrane distance, is determined from the repeat distance d and the membrane thickness d(b). It is shown that an increase in the molar concentration X-DMSO leads to a considerable decrease in the intermembrane distance and that, at X-DMSO = 0.4, the neighboring membranes are virtually in steric contact with each other. The use of the deuterated phospholipid (DMSO-D6) and the contrast variation method makes it possible, for the first time, to determine the number of DMSO molecules strongly bound to the membrane.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000246804500036
DO  - DOI:10.1134/S1063774507030364
UR  - https://juser.fz-juelich.de/record/59134
ER  -