TY  - JOUR
AU  - Hanson, J.
AU  - Hanssen, M.
AU  - Wiese, A.
AU  - Hendriks, M.M.W.B.
AU  - Smeekens, S.
TI  - The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2
JO  - The plant journal
VL  - 53
SN  - 0960-7412
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - PreJuSER-59135
SP  - 935 - 949
PY  - 2008
N1  - Record converted from VDB: 12.11.2012
AB  - Translation of the transcription factor bZIP11 is repressed by sucrose in a process that involves a highly conserved peptide encoded by the 5' leaders of bZIP11 and other plant basic region leucine zipper (bZip) genes. It is likely that a specific signaling pathway operating at physiological sucrose concentrations controls metabolism via a feedback mechanism. In this paper bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis. bZIP11 affects the expression of hundreds of genes with proposed functions in biochemical pathways and signal transduction. The expression levels of approximately 80% of the genes tested are not affected by bZIP11 promoter-mediated overexpression of bZIP11. This suggests that <20% of the identified genes appear to be physiologically relevant targets of bZIP11. ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2 are among the rapidly activated bZIP11 targets, whose induction is independent of protein translation. Transient expression experiments in Arabidopsis protoplasts show that the bZIP11-dependent activation of the ASPARAGINE SYNTHETASE1 gene is dependent on a G-box element present in the promoter. Increased bZIP11 expression leads to decreased proline and increased phenylalanine levels. A model is proposed in which sugar signals control amino acid levels via the bZIP11 transcription factor.
KW  - Amino Acids: metabolism
KW  - Arabidopsis Proteins: genetics
KW  - Arabidopsis Proteins: metabolism
KW  - Aspartate-Ammonia Ligase: genetics
KW  - Aspartate-Ammonia Ligase: metabolism
KW  - Basic-Leucine Zipper Transcription Factors: genetics
KW  - Basic-Leucine Zipper Transcription Factors: metabolism
KW  - Gene Expression Regulation, Plant: physiology
KW  - Proline Oxidase: genetics
KW  - Proline Oxidase: metabolism
KW  - Promoter Regions, Genetic: physiology
KW  - Protein Binding: physiology
KW  - Sucrose: metabolism
KW  - ATB2 protein, Arabidopsis (NLM Chemicals)
KW  - Amino Acids (NLM Chemicals)
KW  - Arabidopsis Proteins (NLM Chemicals)
KW  - Basic-Leucine Zipper Transcription Factors (NLM Chemicals)
KW  - Sucrose (NLM Chemicals)
KW  - Proline Oxidase (NLM Chemicals)
KW  - Aspartate-Ammonia Ligase (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:18088315
UR  - <Go to ISI:>//WOS:000253827600005
DO  - DOI:10.1111/j.1365-313X.2007.03385.x
UR  - https://juser.fz-juelich.de/record/59135
ER  -