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@ARTICLE{Stangler:59381,
      author       = {Stangler, T. and Tran, T. and Hoffmann, S. and Schmidt, H.
                      and Jonas, E. and Willbold, D.},
      title        = {{C}ompetitive displacement of full-length {HIV}-1 {N}ef
                      from the {H}ck {SH}3 domain by a high-affinity artificial
                      peptide},
      journal      = {Biological chemistry},
      volume       = {388},
      issn         = {1431-6730},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {PreJuSER-59381},
      pages        = {611 - 615},
      year         = {2007},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {We studied the interaction of the artificial 12-aa
                      proline-rich peptide PD1 with the SH3 domain of the
                      hematopoietic cell kinase Hck and the peptide's potency in
                      competitively displacing HIV-1 Nef from the Hck SH3 domain.
                      PD1 was obtained from a phage display screen and exhibits
                      exceptional affinity for the Hck SH3 domain (K(d)=0.23
                      microM). Competition experiments using NMR spectroscopy
                      demonstrate that the peptide even displaces Nef from Hck SH3
                      and allow for estimation of the Nef-Hck SH3 dissociation
                      constant (K(d)=0.44 microM), the strongest SH3 ligand
                      interaction known so far. Consequences of this study for
                      novel antiviral concepts are discussed.},
      keywords     = {Binding, Competitive / Gene Products, nef: metabolism /
                      Humans / Peptides: metabolism / Protein Binding /
                      Proto-Oncogene Proteins c-hck: metabolism / nef Gene
                      Products, Human Immunodeficiency Virus / src Homology
                      Domains / Gene Products, nef (NLM Chemicals) / Peptides (NLM
                      Chemicals) / nef Gene Products, Human Immunodeficiency Virus
                      (NLM Chemicals) / HCK protein, human (NLM Chemicals) /
                      Proto-Oncogene Proteins c-hck (NLM Chemicals) / J (WoSType)},
      cin          = {INB-2 / JARA-SIM},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB805 / I:(DE-Juel1)VDB1045},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Biochemistry $\&$ Molecular Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17552908},
      UT           = {WOS:000247141500007},
      doi          = {10.1515/BC.2007.075},
      url          = {https://juser.fz-juelich.de/record/59381},
}