%0 Journal Article
%A Zhernosekov, K. P.
%A Filosofov, D. V.
%A Qaim, S. M.
%A Rösch, F.
%T A Nd-140/Pr-140 radionuclide generator based on physico-chemical transitions in Pr-140 complexes after electron capture decay of Nd-140-DOTA
%J Radiochimica acta
%V 95
%@ 0033-8230
%C München
%I Oldenbourg
%M PreJuSER-59405
%P 319 - 327
%D 2007
%Z Record converted from VDB: 12.11.2012
%X Nd-140 was produced by irradiations of CeO2 and Pr2O3 targets leading to Ce-nat(He-3,xn)Nd-140 and Pr-141(p,2n)Nd-140 nuclear reactions. The practical yield of Nd-140 at EOB in the former reaction over the energy range of E-3He = 33.5 -> 0 MeV amounted to 3.5 MBq/mu A It and in the latter reaction over the energy range of E-p = 18.6 -> 16.2 MeV to 15.5 MBq/mu A h. These values correspond to about 41% and 60% of the respective theoretical values. Successful separations of the radionuclide were performed by means of cation-exchange chromatography resulting in decontamination factors of >= 10(8) and >= 7 x 10(5) for the cerium and praseodymium target materials, respectively. With the no-carrier-added Nd-140 obtained, an efficient Nd-140/Pr-140 radionuclide generator system was developed and evaluated. The principle of the radiochemical separation is based on physico-chemical transitions (hot-atom effects) of the daughter Pr-140 following the electron decay process of Nd-140. The parent radionuclide Nd-140(III) is quantitatively adsorbed on a solid phase matrix in the form of Nd-140-DOTA-conjugated complexes. The daughter nuclide Pr-140 is generated in an ionic species and is easily separated using low volumes of various aqueous eluents. The elution yield is at least 93% if an optimized eluent, such as DTPA solution is applied. The system remains stable at least over three half-lives of Nd-140. with high radiolytic stability and low Nd-140 breakthrough. This radionuclide generator system Nd-140 (T-1/2 = 3.37 d) provides the short-lived positron-emitting radiolanthanide Pr-140 (T-1/2 = 3.4 min) for molecular imaging using positron emission tomography (PET).
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000247310700004
%R 10.1524/ract.2007.95.6.319
%U https://juser.fz-juelich.de/record/59405