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000006000 0247_ $$2DOI$$a10.1016/j.neuroscience.2009.07.067
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000006000 084__ $$2WoS$$aNeurosciences
000006000 1001_ $$0P:(DE-HGF)0$$aHaghir, H.$$b0
000006000 245__ $$aPatterns of neurotransmitter receptor distributions following cortical spreading depression
000006000 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2009
000006000 300__ $$a1340 - 1352
000006000 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000006000 440_0 $$04579$$aNeuroscience$$v163$$x0306-4522$$y4
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000006000 520__ $$aSpreading depression (SD), a self-propagating depolarization of neurons and glia, is believed to play a role in different neurological disorders including migraine aura and acute brain ischaemia. Initiation and propagation of SD modulate excitability of neuronal network. A brief period of excitation heralds SD which is immediately followed first by prolonged nerve cell depression and later by an excitatory phase. The aim of the present study was to characterize local and remote transmitter receptor changes after propagation of cortical SD. Quantitative receptor autoradiography was used to asses 16 transmitter receptor types in combined striatum-hippocampus-cortex slices of the rat 1 h after induction of cortical SD. In neocortical tissues, local increases of glutamate NMDA, AMPA, and kainate receptor binding sites were observed. In addition to up-regulation of ionotropic glutamate receptors, receptor binding sites of GABA(A), muscarinic M1 and M2, adrenergic alpha(1) and alpha(2), and serotonergic 5-HT(2) receptors were increased in the hippocampus. Cortical SD also upregulated NMDA, AMPA, kainate, GABA(A), serotonergic 5-HT(2), adrenergic alpha(2) and dopaminergic D1 receptor binding sites in the striatum. These findings indicate selective changes in several receptors binding sites both in cortical and subcortical regions by SD which may explain delayed excitatory phase after SD. Mapping of receptor changes by cortical SD increases our understanding of the mechanism of SD action in associated neurological disorders.
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000006000 650_2 $$2MeSH$$aAnimals
000006000 650_2 $$2MeSH$$aAutoradiography
000006000 650_2 $$2MeSH$$aCerebral Cortex: physiology
000006000 650_2 $$2MeSH$$aCorpus Striatum: physiology
000006000 650_2 $$2MeSH$$aCortical Spreading Depression: physiology
000006000 650_2 $$2MeSH$$aHippocampus: physiology
000006000 650_2 $$2MeSH$$aMicroelectrodes
000006000 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000006000 650_2 $$2MeSH$$aRats
000006000 650_2 $$2MeSH$$aReceptors, Neurotransmitter: metabolism
000006000 650_7 $$00$$2NLM Chemicals$$aReceptors, Neurotransmitter
000006000 650_7 $$2WoSType$$aJ
000006000 65320 $$2Author$$amigraine headache
000006000 65320 $$2Author$$astroke
000006000 65320 $$2Author$$aepilepsy
000006000 65320 $$2Author$$atransmitter density
000006000 65320 $$2Author$$aautoradiography
000006000 7001_ $$0P:(DE-HGF)0$$aKovac, S.$$b1
000006000 7001_ $$0P:(DE-HGF)0$$aSpeckmann, E.-J.$$b2
000006000 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b3$$uFZJ
000006000 7001_ $$0P:(DE-HGF)0$$aGorji, A.$$b4
000006000 773__ $$0PERI:(DE-600)1498423-4$$a10.1016/j.neuroscience.2009.07.067$$gVol. 163, p. 1340 - 1352$$p1340 - 1352$$q163<1340 - 1352$$tNeuroscience$$v163$$x0306-4522$$y2009
000006000 8567_ $$uhttp://dx.doi.org/10.1016/j.neuroscience.2009.07.067
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