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000060109 0247_ $$2DOI$$a10.1016/j.bbrc.2007.10.085
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000060109 084__ $$2WoS$$aBiochemistry & Molecular Biology
000060109 084__ $$2WoS$$aBiophysics
000060109 1001_ $$0P:(DE-Juel1)VDB65869$$aFunke, S. A.$$b0$$uFZJ
000060109 245__ $$aSingle particle detection of amyloid-ß aggregates associated with Alzheimer's disease
000060109 260__ $$aOrlando, Fla.$$bAcademic Press$$c2007
000060109 300__ $$a902 - 907
000060109 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000060109 440_0 $$0787$$aBiochemical and Biophysical Research Communications$$v364$$x0006-291X
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000060109 520__ $$aAlzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Today, AD can be diagnosed with certainty only post-mortem, by histopathologic staining of Abeta plaques and neurofibrillary tangles in brain tissue sections. We have developed an ultra-sensitive assay potentially suitable for early and non-invasive diagnosis of AD. This highly specific and sensitive assay uses fluorescence correlation spectroscopy (FCS) and is sensitive enough to detect even single aggregates in body fluids of AD patients. First results show a clear distinction between AD diseased people and non-demented controls by analysing cerebrospinal fluids (CSF) by confocal scanning of surface captured Abeta aggregates and subsequent two-dimensional fluorescence intensity distribution analysis.
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000060109 588__ $$aDataset connected to Web of Science, Pubmed
000060109 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000060109 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000060109 650_2 $$2MeSH$$aAmyloid beta-Peptides: analysis
000060109 650_2 $$2MeSH$$aAmyloid beta-Peptides: ultrastructure
000060109 650_2 $$2MeSH$$aCerebrospinal Fluid: cytology
000060109 650_2 $$2MeSH$$aCerebrospinal Fluid: metabolism
000060109 650_2 $$2MeSH$$aHumans
000060109 650_2 $$2MeSH$$aImage Enhancement: methods
000060109 650_2 $$2MeSH$$aMicroscopy, Confocal: methods
000060109 650_2 $$2MeSH$$aMicroscopy, Fluorescence: methods
000060109 650_2 $$2MeSH$$aParticle Size
000060109 650_7 $$00$$2NLM Chemicals$$aAmyloid beta-Peptides
000060109 650_7 $$2WoSType$$aJ
000060109 65320 $$2Author$$aAlzheimer's disease
000060109 65320 $$2Author$$aearly diagnosis
000060109 65320 $$2Author$$aamyloid-beta aggregates
000060109 65320 $$2Author$$afluorescence correlation spectroscopy (FCS)
000060109 65320 $$2Author$$aprotein misfolding diseases
000060109 7001_ $$0P:(DE-Juel1)VDB65870$$aBirkmann, E.$$b1$$uFZJ
000060109 7001_ $$0P:(DE-Juel1)VDB65871$$aHenke, F.$$b2$$uFZJ
000060109 7001_ $$0P:(DE-Juel1)VDB72722$$aGörtz, P.$$b3$$uFZJ
000060109 7001_ $$0P:(DE-Juel1)VDB72723$$aLange-Asschenfeldt, C.$$b4$$uFZJ
000060109 7001_ $$0P:(DE-Juel1)VDB2263$$aRiesner, D.$$b5$$uFZJ
000060109 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b6$$uFZJ
000060109 773__ $$0PERI:(DE-600)1461396-7$$a10.1016/j.bbrc.2007.10.085$$gVol. 364, p. 902 - 907$$p902 - 907$$q364<902 - 907$$tBiochemical and biophysical research communications$$v364$$x0006-291X$$y2007
000060109 8567_ $$uhttp://dx.doi.org/10.1016/j.bbrc.2007.10.085
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