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@ARTICLE{Funke:60109,
      author       = {Funke, S. A. and Birkmann, E. and Henke, F. and Görtz, P.
                      and Lange-Asschenfeldt, C. and Riesner, D. and Willbold, D.},
      title        = {{S}ingle particle detection of amyloid-ß aggregates
                      associated with {A}lzheimer's disease},
      journal      = {Biochemical and biophysical research communications},
      volume       = {364},
      issn         = {0006-291X},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {PreJuSER-60109},
      pages        = {902 - 907},
      year         = {2007},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Alzheimer's disease (AD) is a progressive neurodegenerative
                      disorder and the most common cause of dementia. Today, AD
                      can be diagnosed with certainty only post-mortem, by
                      histopathologic staining of Abeta plaques and
                      neurofibrillary tangles in brain tissue sections. We have
                      developed an ultra-sensitive assay potentially suitable for
                      early and non-invasive diagnosis of AD. This highly specific
                      and sensitive assay uses fluorescence correlation
                      spectroscopy (FCS) and is sensitive enough to detect even
                      single aggregates in body fluids of AD patients. First
                      results show a clear distinction between AD diseased people
                      and non-demented controls by analysing cerebrospinal fluids
                      (CSF) by confocal scanning of surface captured Abeta
                      aggregates and subsequent two-dimensional fluorescence
                      intensity distribution analysis.},
      keywords     = {Alzheimer Disease: cerebrospinal fluid / Alzheimer Disease:
                      diagnosis / Amyloid beta-Peptides: analysis / Amyloid
                      beta-Peptides: ultrastructure / Cerebrospinal Fluid:
                      cytology / Cerebrospinal Fluid: metabolism / Humans / Image
                      Enhancement: methods / Microscopy, Confocal: methods /
                      Microscopy, Fluorescence: methods / Particle Size / Amyloid
                      beta-Peptides (NLM Chemicals) / J (WoSType)},
      cin          = {INB-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB805},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Biophysics},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17963690},
      UT           = {WOS:000251358500031},
      doi          = {10.1016/j.bbrc.2007.10.085},
      url          = {https://juser.fz-juelich.de/record/60109},
}