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000060181 0247_ $$2DOI$$a10.1073/pnas.0703137104
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000060181 041__ $$aeng
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000060181 084__ $$2WoS$$aMultidisciplinary Sciences
000060181 1001_ $$0P:(DE-HGF)0$$aMuhs, A.$$b0
000060181 245__ $$aLiposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice
000060181 260__ $$aWashington, DC$$bAcademy$$c2007
000060181 300__ $$a9810 - 9815
000060181 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000060181 440_0 $$05100$$aProceedings of the National Academy of Sciences of the United States of America$$v104$$x0027-8424$$y23
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000060181 520__ $$aWe investigated the therapeutic effects of two different versions of Abeta(1-15 (16)) liposome-based vaccines. Inoculation of APP-V717IxPS-1 (APPxPS-1) double-transgenic mice with tetra-palmitoylated amyloid 1-15 peptide (palmAbeta(1-15)), or with amyloid 1-16 peptide (PEG-Abeta(1-16)) linked to a polyethyleneglycol spacer at each end, and embedded within a liposome membrane, elicited fast immune responses with identical binding epitopes. PalmAbeta(1-15) liposomal vaccine elicited an immune response that restored the memory defect of the mice, whereas that of PEG-Abeta(1-16) had no such effect. Immunoglobulins that were generated were predominantly of the IgG class with palmAbeta(1-15), whereas those elicited by PEG-Abeta(1-16) were primarily of the IgM class. The IgG subclasses of the antibodies generated by both vaccines were mostly IgG2b indicating noninflammatory Th2 isotype. CD and NMR revealed predominantly beta-sheet conformation of palmAbeta(1-15) and random coil of PEG-Abeta(1-16). We conclude that the association with liposomes induced a variation of the immunogenic structures and thereby different immunogenicities. This finding supports the hypothesis that Alzheimer's disease is a "conformational" disease, implying that antibodies against amyloid sequences in the beta-sheet conformation are preferred as potential therapeutic agents.
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000060181 588__ $$aDataset connected to Web of Science, Pubmed
000060181 650_2 $$2MeSH$$aAlzheimer Disease: prevention & control
000060181 650_2 $$2MeSH$$aAlzheimer Vaccines: immunology
000060181 650_2 $$2MeSH$$aAlzheimer Vaccines: pharmacology
000060181 650_2 $$2MeSH$$aAmyloid beta-Peptides: immunology
000060181 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000060181 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: genetics
000060181 650_2 $$2MeSH$$aAnalysis of Variance
000060181 650_2 $$2MeSH$$aAnimals
000060181 650_2 $$2MeSH$$aAntigens: immunology
000060181 650_2 $$2MeSH$$aBrain: immunology
000060181 650_2 $$2MeSH$$aBrain: metabolism
000060181 650_2 $$2MeSH$$aCytokines: metabolism
000060181 650_2 $$2MeSH$$aEnzyme-Linked Immunosorbent Assay
000060181 650_2 $$2MeSH$$aEpitope Mapping
000060181 650_2 $$2MeSH$$aLiposomes: immunology
000060181 650_2 $$2MeSH$$aMice
000060181 650_2 $$2MeSH$$aMice, Transgenic
000060181 650_2 $$2MeSH$$aNuclear Magnetic Resonance, Biomolecular
000060181 650_2 $$2MeSH$$aOligopeptides: genetics
000060181 650_2 $$2MeSH$$aPeptide Fragments: immunology
000060181 650_2 $$2MeSH$$aRecognition (Psychology): drug effects
000060181 650_7 $$00$$2NLM Chemicals$$aAlzheimer Vaccines
000060181 650_7 $$00$$2NLM Chemicals$$aAmyloid beta-Peptides
000060181 650_7 $$00$$2NLM Chemicals$$aAmyloid beta-Protein Precursor
000060181 650_7 $$00$$2NLM Chemicals$$aAntigens
000060181 650_7 $$00$$2NLM Chemicals$$aCytokines
000060181 650_7 $$00$$2NLM Chemicals$$aLiposomes
000060181 650_7 $$00$$2NLM Chemicals$$aOligopeptides
000060181 650_7 $$00$$2NLM Chemicals$$aPS1 antigen
000060181 650_7 $$00$$2NLM Chemicals$$aPeptide Fragments
000060181 650_7 $$2WoSType$$aJ
000060181 65320 $$2Author$$aAlzheimer's disease
000060181 65320 $$2Author$$abeta-amyloid
000060181 65320 $$2Author$$avaccine
000060181 7001_ $$0P:(DE-HGF)0$$aHickmann, D.T.$$b1
000060181 7001_ $$0P:(DE-HGF)0$$aPihlgren, M.$$b2
000060181 7001_ $$0P:(DE-HGF)0$$aChuard, N.$$b3
000060181 7001_ $$0P:(DE-HGF)0$$aGiriens, V.$$b4
000060181 7001_ $$0P:(DE-HGF)0$$aMeerschman, C.$$b5
000060181 7001_ $$0P:(DE-HGF)0$$avan der Auwera, I.$$b6
000060181 7001_ $$0P:(DE-HGF)0$$avan Leuven, F.$$b7
000060181 7001_ $$0P:(DE-HGF)0$$aSugawara, M.$$b8
000060181 7001_ $$0P:(DE-HGF)0$$aWeingertner, M.C.$$b9
000060181 7001_ $$0P:(DE-HGF)0$$aBechinger, B.$$b10
000060181 7001_ $$0P:(DE-HGF)0$$aGreferath, R.$$b11
000060181 7001_ $$0P:(DE-HGF)0$$aKolonko, N.$$b12
000060181 7001_ $$0P:(DE-Juel1)VDB72731$$aNagel-Steger, L.$$b13$$uFZJ
000060181 7001_ $$0P:(DE-HGF)0$$aRiesner, D.$$b14
000060181 7001_ $$0P:(DE-HGF)0$$aBrady, R.O.$$b15
000060181 7001_ $$0P:(DE-HGF)0$$aPfeifer, A.$$b16
000060181 7001_ $$0P:(DE-HGF)0$$aNicolau, C.$$b17
000060181 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.0703137104$$gVol. 104, p. 9810 - 9815$$p9810 - 9815$$q104<9810 - 9815$$tProceedings of the National Academy of Sciences of the United States of America$$v104$$x0027-8424$$y2007
000060181 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887581
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