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@ARTICLE{Muhs:60181,
      author       = {Muhs, A. and Hickmann, D.T. and Pihlgren, M. and Chuard, N.
                      and Giriens, V. and Meerschman, C. and van der Auwera, I.
                      and van Leuven, F. and Sugawara, M. and Weingertner, M.C.
                      and Bechinger, B. and Greferath, R. and Kolonko, N. and
                      Nagel-Steger, L. and Riesner, D. and Brady, R.O. and
                      Pfeifer, A. and Nicolau, C.},
      title        = {{L}iposomal vaccines with conformation-specific amyloid
                      peptide antigens define immune response and efficacy in
                      {APP} transgenic mice},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {104},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {Academy},
      reportid     = {PreJuSER-60181},
      pages        = {9810 - 9815},
      year         = {2007},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {We investigated the therapeutic effects of two different
                      versions of Abeta(1-15 (16)) liposome-based vaccines.
                      Inoculation of APP-V717IxPS-1 (APPxPS-1) double-transgenic
                      mice with tetra-palmitoylated amyloid 1-15 peptide
                      (palmAbeta(1-15)), or with amyloid 1-16 peptide
                      (PEG-Abeta(1-16)) linked to a polyethyleneglycol spacer at
                      each end, and embedded within a liposome membrane, elicited
                      fast immune responses with identical binding epitopes.
                      PalmAbeta(1-15) liposomal vaccine elicited an immune
                      response that restored the memory defect of the mice,
                      whereas that of PEG-Abeta(1-16) had no such effect.
                      Immunoglobulins that were generated were predominantly of
                      the IgG class with palmAbeta(1-15), whereas those elicited
                      by PEG-Abeta(1-16) were primarily of the IgM class. The IgG
                      subclasses of the antibodies generated by both vaccines were
                      mostly IgG2b indicating noninflammatory Th2 isotype. CD and
                      NMR revealed predominantly beta-sheet conformation of
                      palmAbeta(1-15) and random coil of PEG-Abeta(1-16). We
                      conclude that the association with liposomes induced a
                      variation of the immunogenic structures and thereby
                      different immunogenicities. This finding supports the
                      hypothesis that Alzheimer's disease is a "conformational"
                      disease, implying that antibodies against amyloid sequences
                      in the beta-sheet conformation are preferred as potential
                      therapeutic agents.},
      keywords     = {Alzheimer Disease: prevention $\&$ control / Alzheimer
                      Vaccines: immunology / Alzheimer Vaccines: pharmacology /
                      Amyloid beta-Peptides: immunology / Amyloid beta-Peptides:
                      metabolism / Amyloid beta-Protein Precursor: genetics /
                      Analysis of Variance / Animals / Antigens: immunology /
                      Brain: immunology / Brain: metabolism / Cytokines:
                      metabolism / Enzyme-Linked Immunosorbent Assay / Epitope
                      Mapping / Liposomes: immunology / Mice / Mice, Transgenic /
                      Nuclear Magnetic Resonance, Biomolecular / Oligopeptides:
                      genetics / Peptide Fragments: immunology / Recognition
                      (Psychology): drug effects / Alzheimer Vaccines (NLM
                      Chemicals) / Amyloid beta-Peptides (NLM Chemicals) / Amyloid
                      beta-Protein Precursor (NLM Chemicals) / Antigens (NLM
                      Chemicals) / Cytokines (NLM Chemicals) / Liposomes (NLM
                      Chemicals) / Oligopeptides (NLM Chemicals) / PS1 antigen
                      (NLM Chemicals) / Peptide Fragments (NLM Chemicals) / J
                      (WoSType)},
      cin          = {INB-2},
      ddc          = {000},
      cid          = {I:(DE-Juel1)VDB805},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Multidisciplinary Sciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17517595},
      pmc          = {pmc:PMC1887581},
      UT           = {WOS:000247114100049},
      doi          = {10.1073/pnas.0703137104},
      url          = {https://juser.fz-juelich.de/record/60181},
}