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000060183 084__ $$2WoS$$aBiochemistry & Molecular Biology
000060183 1001_ $$0P:(DE-Juel1)VDB72772$$aElfrink, K.$$b0$$uFZJ
000060183 245__ $$aInteraction of the cellular prion protein with raft-like lipid membranes
000060183 260__ $$aBerlin [u.a.]$$bde Gruyter$$c2007
000060183 300__ $$a79 - 89
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000060183 440_0 $$09042$$aBiological Chemistry$$v388$$x1431-6730$$y1
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000060183 520__ $$aThe number of metal ions required for phosphoryl transfer in restriction endonucleases is still an unresolved question in molecular biology. The two Ca(2+) and Mn(2+) ions observed in the pre- and post-reactive complexes of BamHI conform to the classical two-metal ion choreography. We probed the Mg(2+) cofactor positions at the active site of BamHI by molecular dynamics simulations with one and two metal ions present and identified several catalytically relevant sites. These can mark the pathway of a single ion during catalysis, suggesting its critical role, while a regulatory function is proposed for a possible second ion.
000060183 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
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000060183 65320 $$2Author$$abiacore
000060183 65320 $$2Author$$aGPI anchor
000060183 65320 $$2Author$$aprion
000060183 65320 $$2Author$$aPrPc
000060183 65320 $$2Author$$asurface plasmon resonance
000060183 650_2 $$2MeSH$$aBinding Sites
000060183 650_2 $$2MeSH$$aCalcium: metabolism
000060183 650_2 $$2MeSH$$aCrystallography, X-Ray
000060183 650_2 $$2MeSH$$aDeoxyribonuclease BamHI: chemistry
000060183 650_2 $$2MeSH$$aDeoxyribonuclease BamHI: metabolism
000060183 650_2 $$2MeSH$$aMagnesium: metabolism
000060183 650_2 $$2MeSH$$aManganese: metabolism
000060183 650_2 $$2MeSH$$aMetals: metabolism
000060183 650_2 $$2MeSH$$aModels, Molecular
000060183 650_2 $$2MeSH$$aProtein Structure, Secondary
000060183 650_2 $$2MeSH$$aStructure-Activity Relationship
000060183 650_7 $$00$$2NLM Chemicals$$aMetals
000060183 650_7 $$07439-95-4$$2NLM Chemicals$$aMagnesium
000060183 650_7 $$07439-96-5$$2NLM Chemicals$$aManganese
000060183 650_7 $$07440-70-2$$2NLM Chemicals$$aCalcium
000060183 650_7 $$0EC 3.1.21.-$$2NLM Chemicals$$aDeoxyribonuclease BamHI
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000060183 7001_ $$0P:(DE-Juel1)VDB72731$$aNagel-Steger, L.$$b1$$uFZJ
000060183 7001_ $$0P:(DE-HGF)0$$aRiesner, D.$$b2
000060183 773__ $$0PERI:(DE-600)1466062-3$$gVol. 388, p. 79 - 89$$p79 - 89$$q388<79 - 89$$tBiological chemistry$$v388$$x1431-6730$$y2007
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