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@ARTICLE{Piepehoff:61191,
      author       = {Piepehoff, P. and Hömke, L. and Schneider, F. and Habel,
                      U. and Shah, J. N. and Zilles, K. and Amunts, K.},
      title        = {{D}eformation field morphometry reveals age-related
                      structural differences between the brains of adults up to 51
                      years},
      journal      = {The journal of neuroscience},
      volume       = {28},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PreJuSER-61191},
      pages        = {828 - 842},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Age-related differences in the anatomical structure of the
                      brains from 51 healthy male subjects (age: 18-51 years) were
                      analyzed by deformation field morphometry in a
                      cross-sectional study. The magnetic resonance images of the
                      brains were nonlinearly registered onto the image of a
                      reference brain: the registration algorithm simulated an
                      elastic deformation of each brain (source brain) so that the
                      voxelwise intensity differences with the reference brain
                      were minimized. A three-dimensional deformation field was
                      calculated for each source brain that encoded the anatomical
                      differences between the source brain and the reference
                      brain. Maps of voxelwise volume differences between each
                      subject's brain and the reference brain were analyzed. They
                      showed age-related differences in anatomically defined
                      regions of interest. Major volume decreases were found in
                      the white matter and nuclei of the cerebellum, as well as in
                      the ventral thalamic nuclei and the somatosensory and motor
                      cortices, including the underlying white matter. These
                      findings suggest that aging between the second and sixth
                      decade predominantly affects subcortical nuclei and cortical
                      areas of the sensorimotor system, forming the
                      cortico-rubro-cerebello-thalamo-cortical pathway.
                      Additionally, a pronounced age-related decline in volume was
                      observed in the rostral anterior cingulate, orbitofrontal,
                      and lateral prefrontal cortices. Almost no differences were
                      observed in the occipital and temporal lobes. The ventricles
                      showed a pronounced widening. Remarkably, these volume
                      differences occur at a relatively early period of the human
                      life span. It may be speculated that these structural
                      differences accompany or precede differences in sensorimotor
                      functions and behavior.},
      keywords     = {Adolescent / Adult / Aging: pathology / Brain: pathology /
                      Cross-Sectional Studies / Humans / Magnetic Resonance
                      Imaging: methods / Male / Middle Aged / J (WoSType)},
      cin          = {INB-3 / JARA-BRAIN},
      ddc          = {590},
      cid          = {I:(DE-Juel1)INB-3-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18216191},
      UT           = {WOS:000252777900006},
      doi          = {10.1523/JNEUROSCI.3732-07.2008},
      url          = {https://juser.fz-juelich.de/record/61191},
}