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| Hauptseite > Publikationsdatenbank > Deformation field morphometry reveals age-related structural differences between the brains of adults up to 51 years > print |
| Hauptseite > Publikationsdatenbank > Deformation field morphometry reveals age-related structural differences between the brains of adults up to 51 years > print |
| 001 | 61191 | ||
| 005 | 20200423204603.0 | ||
| 024 | 7 | _ | |a pmid:18216191 |2 pmid |
| 024 | 7 | _ | |a 10.1523/JNEUROSCI.3732-07.2008 |2 DOI |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 590 |
| 084 | _ | _ | |2 WoS |a Neurosciences |
| 100 | 1 | _ | |a Piepehoff, P. |b 0 |u FZJ |0 P:(DE-Juel1)VDB74025 |
| 245 | _ | _ | |a Deformation field morphometry reveals age-related structural differences between the brains of adults up to 51 years |
| 260 | _ | _ | |a Washington, DC |b Soc. |c 2008 |
| 300 | _ | _ | |a 828 - 842 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
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| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a Journal of Neuroscience |x 0270-6474 |0 3603 |y 4 |v 28 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a Age-related differences in the anatomical structure of the brains from 51 healthy male subjects (age: 18-51 years) were analyzed by deformation field morphometry in a cross-sectional study. The magnetic resonance images of the brains were nonlinearly registered onto the image of a reference brain: the registration algorithm simulated an elastic deformation of each brain (source brain) so that the voxelwise intensity differences with the reference brain were minimized. A three-dimensional deformation field was calculated for each source brain that encoded the anatomical differences between the source brain and the reference brain. Maps of voxelwise volume differences between each subject's brain and the reference brain were analyzed. They showed age-related differences in anatomically defined regions of interest. Major volume decreases were found in the white matter and nuclei of the cerebellum, as well as in the ventral thalamic nuclei and the somatosensory and motor cortices, including the underlying white matter. These findings suggest that aging between the second and sixth decade predominantly affects subcortical nuclei and cortical areas of the sensorimotor system, forming the cortico-rubro-cerebello-thalamo-cortical pathway. Additionally, a pronounced age-related decline in volume was observed in the rostral anterior cingulate, orbitofrontal, and lateral prefrontal cortices. Almost no differences were observed in the occipital and temporal lobes. The ventricles showed a pronounced widening. Remarkably, these volume differences occur at a relatively early period of the human life span. It may be speculated that these structural differences accompany or precede differences in sensorimotor functions and behavior. |
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| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Adolescent |
| 650 | _ | 2 | |2 MeSH |a Adult |
| 650 | _ | 2 | |2 MeSH |a Aging: pathology |
| 650 | _ | 2 | |2 MeSH |a Brain: pathology |
| 650 | _ | 2 | |2 MeSH |a Cross-Sectional Studies |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Magnetic Resonance Imaging: methods |
| 650 | _ | 2 | |2 MeSH |a Male |
| 650 | _ | 2 | |2 MeSH |a Middle Aged |
| 650 | _ | 7 | |a J |2 WoSType |
| 653 | 2 | 0 | |2 Author |a aging |
| 653 | 2 | 0 | |2 Author |a morphometry |
| 653 | 2 | 0 | |2 Author |a cerebellum |
| 653 | 2 | 0 | |2 Author |a thalamus |
| 653 | 2 | 0 | |2 Author |a cingulate |
| 653 | 2 | 0 | |2 Author |a sensorimotor |
| 700 | 1 | _ | |a Hömke, L. |b 1 |u FZJ |0 P:(DE-Juel1)VDB33810 |
| 700 | 1 | _ | |a Schneider, F. |b 2 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Habel, U. |b 3 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Shah, J. N. |b 4 |u FZJ |0 P:(DE-Juel1)131794 |
| 700 | 1 | _ | |a Zilles, K. |b 5 |u FZJ |0 P:(DE-Juel1)131714 |
| 700 | 1 | _ | |a Amunts, K. |b 6 |u FZJ |0 P:(DE-Juel1)131631 |
| 773 | _ | _ | |a 10.1523/JNEUROSCI.3732-07.2008 |g Vol. 28, p. 828 - 842 |p 828 - 842 |q 28<828 - 842 |0 PERI:(DE-600)1475274-8 |t The @journal of neuroscience |v 28 |y 2008 |x 0270-6474 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1523/JNEUROSCI.3732-07.2008 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/61191/files/828.full.pdf |y OpenAccess |
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