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000061424 0247_ $$2DOI$$a10.1007/s00216-007-1647-7
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000061424 084__ $$2WoS$$aBiochemical Research Methods
000061424 084__ $$2WoS$$aChemistry, Analytical
000061424 1001_ $$0P:(DE-HGF)0$$aMach, T.$$b0
000061424 245__ $$aMiniaturized planar lipid bilayer: increased stability, low electric noise and fast fluid perfusion
000061424 260__ $$aBerlin$$bSpringer$$c2008
000061424 300__ $$a841 - 846
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000061424 440_0 $$08664$$aAnalytical and Bioanalytical Chemistry$$v390$$x1618-2642
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000061424 520__ $$aA microfluidic device was designed allowing the formation of a planar lipid bilayer across a micron-sized aperture in a glass slide sandwiched between two polydimethylsiloxane channel systems. By flushing giant unilamellar vesicles through a 500-microm-wide channel above the hole, we were able to form a planar lipid bilayer across the hole, resulting in a giga-seal. We demonstrate incorporation of biological nanopores into the bilayer. This miniaturized system offers noise recordings comparable to open head-stage noise (under 1 pA RMS at 10 kHz), fast precision perfusion on each side of the membrane and the use of nanoliter analyte volumes. This technique shows a promising potential for automation and parallelization of electrophysiological setups.
000061424 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000061424 588__ $$aDataset connected to Web of Science, Pubmed
000061424 650_2 $$2MeSH$$aCytoplasm: metabolism
000061424 650_2 $$2MeSH$$aDimethylpolysiloxanes: chemistry
000061424 650_2 $$2MeSH$$aElectrochemistry: methods
000061424 650_2 $$2MeSH$$aElectrophysiology: instrumentation
000061424 650_2 $$2MeSH$$aElectrophysiology: methods
000061424 650_2 $$2MeSH$$aEquipment Design
000061424 650_2 $$2MeSH$$aIons
000061424 650_2 $$2MeSH$$aLipid Bilayers: chemistry
000061424 650_2 $$2MeSH$$aLiposomes: chemistry
000061424 650_2 $$2MeSH$$aMicrofluidic Analytical Techniques
000061424 650_2 $$2MeSH$$aMiniaturization
000061424 650_2 $$2MeSH$$aNanotechnology: methods
000061424 650_2 $$2MeSH$$aPatch-Clamp Techniques
000061424 650_2 $$2MeSH$$aPerfusion
000061424 650_2 $$2MeSH$$aSilicones: chemistry
000061424 650_2 $$2MeSH$$aSolvents: chemistry
000061424 650_7 $$00$$2NLM Chemicals$$aDimethylpolysiloxanes
000061424 650_7 $$00$$2NLM Chemicals$$aIons
000061424 650_7 $$00$$2NLM Chemicals$$aLipid Bilayers
000061424 650_7 $$00$$2NLM Chemicals$$aLiposomes
000061424 650_7 $$00$$2NLM Chemicals$$aSilicones
000061424 650_7 $$00$$2NLM Chemicals$$aSolvents
000061424 650_7 $$063148-62-9$$2NLM Chemicals$$abaysilon
000061424 650_7 $$2WoSType$$aJ
000061424 65320 $$2Author$$amicrofluidics
000061424 65320 $$2Author$$aplanar bilayer
000061424 65320 $$2Author$$aelectrophysiology
000061424 65320 $$2Author$$amembrane channel
000061424 7001_ $$0P:(DE-HGF)0$$aChimerel, C.$$b1
000061424 7001_ $$0P:(DE-HGF)0$$aFritz, J.$$b2
000061424 7001_ $$0P:(DE-HGF)0$$aFertig, N.$$b3
000061424 7001_ $$0P:(DE-HGF)0$$aWinterhalter, M.$$b4
000061424 7001_ $$0P:(DE-Juel1)VDB74440$$aFütterer, C.$$b5$$uFZJ
000061424 773__ $$0PERI:(DE-600)1459122-4$$a10.1007/s00216-007-1647-7$$gVol. 390, p. 841 - 846$$p841 - 846$$q390<841 - 846$$tAnalytical and bioanalytical chemistry$$v390$$x1618-2642$$y2008
000061424 8567_ $$uhttp://dx.doi.org/10.1007/s00216-007-1647-7
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000061424 9201_ $$0I:(DE-Juel1)VDB804$$d31.12.2008$$gINB$$kINB-1$$lZelluläre Biophysik$$x0
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