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@ARTICLE{Mach:61424,
      author       = {Mach, T. and Chimerel, C. and Fritz, J. and Fertig, N. and
                      Winterhalter, M. and Fütterer, C.},
      title        = {{M}iniaturized planar lipid bilayer: increased stability,
                      low electric noise and fast fluid perfusion},
      journal      = {Analytical and bioanalytical chemistry},
      volume       = {390},
      issn         = {1618-2642},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {PreJuSER-61424},
      pages        = {841 - 846},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {A microfluidic device was designed allowing the formation
                      of a planar lipid bilayer across a micron-sized aperture in
                      a glass slide sandwiched between two polydimethylsiloxane
                      channel systems. By flushing giant unilamellar vesicles
                      through a 500-microm-wide channel above the hole, we were
                      able to form a planar lipid bilayer across the hole,
                      resulting in a giga-seal. We demonstrate incorporation of
                      biological nanopores into the bilayer. This miniaturized
                      system offers noise recordings comparable to open head-stage
                      noise (under 1 pA RMS at 10 kHz), fast precision perfusion
                      on each side of the membrane and the use of nanoliter
                      analyte volumes. This technique shows a promising potential
                      for automation and parallelization of electrophysiological
                      setups.},
      keywords     = {Cytoplasm: metabolism / Dimethylpolysiloxanes: chemistry /
                      Electrochemistry: methods / Electrophysiology:
                      instrumentation / Electrophysiology: methods / Equipment
                      Design / Ions / Lipid Bilayers: chemistry / Liposomes:
                      chemistry / Microfluidic Analytical Techniques /
                      Miniaturization / Nanotechnology: methods / Patch-Clamp
                      Techniques / Perfusion / Silicones: chemistry / Solvents:
                      chemistry / Dimethylpolysiloxanes (NLM Chemicals) / Ions
                      (NLM Chemicals) / Lipid Bilayers (NLM Chemicals) / Liposomes
                      (NLM Chemicals) / Silicones (NLM Chemicals) / Solvents (NLM
                      Chemicals) / baysilon (NLM Chemicals) / J (WoSType)},
      cin          = {INB-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB804},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Biochemical Research Methods / Chemistry, Analytical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17972068},
      UT           = {WOS:000252417800008},
      doi          = {10.1007/s00216-007-1647-7},
      url          = {https://juser.fz-juelich.de/record/61424},
}