TY - JOUR AU - Kaupp, U. B. AU - Kashikar, N.D. AU - Weyand, I. TI - Mechanisms of sperm chemotaxis JO - Annual review of physiology VL - 70 SN - 0066-4278 CY - Stanford, Calif. PB - Annual Review [u.a.] M1 - PreJuSER-61426 SP - 93 - 117 PY - 2008 N1 - Record converted from VDB: 12.11.2012 AB - Sperm are attracted by chemical factors that are released by the egg-a process called chemotaxis. Most of our knowledge on sperm chemotaxis originates from the study of marine invertebrates. In recent years, the main features of the chemotactic signaling pathway and the swimming behavior evoked by chemoattractants have been elucidated in sea urchins. In contrast, our understanding of mammalian sperm chemotaxis is still rudimentary and subject to an ongoing debate. In this review, we raise new questions and discuss current concepts of sperm chemotaxis. Finally, we highlight commonalities and differences of sensory signaling in sperm, photoreceptors, and olfactory neurons. KW - Animals KW - Chemotaxis: physiology KW - Humans KW - Male KW - Signal Transduction: physiology KW - Sperm Motility: physiology KW - Spermatozoa: cytology KW - Spermatozoa: physiology KW - J (WoSType) LB - PUB:(DE-HGF)16 C6 - pmid:17988206 UR - <Go to ISI:>//WOS:000254489400005 DO - DOI:10.1146/annurev.physiol.70.113006.100654 UR - https://juser.fz-juelich.de/record/61426 ER -