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@ARTICLE{Herzog:61650,
      author       = {Herzog, H. and Tellmann, L. and Scholten, B. and Coenen, H.
                      H. and Qaim, S. M.},
      title        = {{PET} imaging problems with the non-standard positron
                      emitters {Y}ttrium-86 and {I}odine-124},
      journal      = {The quarterly journal of nuclear medicine and mol},
      volume       = {52},
      issn         = {1827-1936},
      address      = {Torino},
      publisher    = {Ed. Minerva Medica},
      reportid     = {PreJuSER-61650},
      pages        = {159 - 165},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Positron emission tomography (PET) imaging of non-standard
                      positron emitters is influenced by gamma-coincidences, i.e.
                      false coincidences produced by the coincident detection of
                      an annihilation photon and a gamma-ray simultaneously
                      emitted with the positron. The extent to which the PET study
                      is disturbed by this effect is dependent on the kind of the
                      positron emitter used, the kind and position of the object,
                      the acquisition mode, i.e. the optional use of septa, and
                      the reconstruction program. In order to demonstrate and
                      study imaging problems with non-standard positron emitters,
                      a phantom was scanned containing non-radioactive rods with
                      different absorption materials and filled with either I-124
                      or Y-86 in the bidimensional (2D) as well as tridimensional
                      (3D) acquisition mode.Methods. For reconstruction, the PET
                      manufacturer's standard software without any modification
                      was used. To reduce errors caused by the gamma
                      -coincidences, a simple linear background subtraction,
                      estimated from the counts at the scanner's external radius,
                      was applied.Results. Without background subtraction,
                      apparent positive and negative "radioactivity
                      concentrations" were found in regions of interest positioned
                      over the nonradioactive rods with values higher for Y-86
                      compared to I-124 and also higher for 3D compared to 2D. A
                      complete subtraction of the background led to erroneous
                      results. The errors in the phantom's non-radioactive rods
                      and the difference between measured and true radioactivity
                      became minimum, when about $75\%$ of the background was
                      subtracted. This refers to both the 2D and 3D
                      mode.Conclusion. Quantitation problems with the non-standard
                      positron emitters I-124 and Y-86 could be minimized in the
                      phantom study examined here by using a simple background
                      subtraction together with the manufacturer's standard
                      correction and reconstruction procedures.},
      keywords     = {J (WoSType)},
      cin          = {INB-3 / INB-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INB-3-20090406 / I:(DE-Juel1)VDB807},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Radiology, Nuclear Medicine $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000255966100009},
      url          = {https://juser.fz-juelich.de/record/61650},
}