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@ARTICLE{Waser:6186,
      author       = {Waser, R. and Valov, I.},
      title        = {{E}lectrochemical reactions in nanoionics - towards future
                      resistive switching memories},
      journal      = {Journal of the Electrochemical Society},
      volume       = {25},
      issn         = {0013-4651},
      address      = {Pennington, NJ},
      publisher    = {Electrochemical Society},
      reportid     = {PreJuSER-6186},
      pages        = {431 - 437},
      year         = {2009},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {This open-label extension evaluated the long-term efficacy
                      and tolerability of rufinamide in patients with
                      Lennox-Gastaut syndrome (LGS) who had previously completed a
                      12-week double-blind study.In total, 124 patients (aged 4-37
                      years), receiving 1-3 concomitant antiepileptic drugs, were
                      treated with rufinamide approximately 25-60 mg/kg/day.
                      Efficacy was assessed by seizure frequency; tolerability by
                      adverse events (AEs) and laboratory tests.Overall, patients
                      were treated with rufinamide for a median (range) of 432
                      (10-1149) days. Reductions in seizure frequency were
                      observed throughout the study; during the last 12 months of
                      treatment, $41.0\%$ and $47.9\%$ of patients had > or =
                      $50\%$ reduction in total and tonic-atonic seizure
                      frequency, respectively. The most common AEs were vomiting
                      $(30.6\%)$ and pyrexia $(25.8\%).In$ this open-label
                      extension, rufinamide appeared to be an effective long-term
                      adjunctive therapy for the treatment of LGS-associated
                      seizures in children and young adults.},
      cin          = {IFF-6 / JARA-FIT},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB786 / $I:(DE-82)080009_20140620$},
      pnm          = {Grundlagen für zukünftige Informationstechnologien},
      pid          = {G:(DE-Juel1)FUEK412},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000338086300041},
      doi          = {10.1149/1.3206642},
      url          = {https://juser.fz-juelich.de/record/6186},
}