TY  - JOUR
AU  - Huebner, T.
AU  - Vloet, T. D.
AU  - Marx, I.
AU  - Konrad, K.
AU  - Fink, G. R.
AU  - Herpertz, S.
AU  - Herpertz-Dahlmann, B.
TI  - Morphometric brain abnormalities in boys with conduct disorder
JO  - Journal of the American Academy of Child and Adolescent Psychiatry
VL  - 47
SN  - 0890-8567
CY  - Kidlington [u.a.]
PB  - Elsevier
M1  - PreJuSER-62197
SP  - 540 - 547
PY  - 2008
N1  - Record converted from VDB: 12.11.2012
AB  - Children with the early-onset type of conduct disorder (CD) are at high risk for developing an antisocial personality disorder. Although there have been several neuroimaging studies on morphometric differences in adults with antisocial personality disorder, little is known about structural brain aberrations in boys with CD.Magnetic resonance imaging and voxel-based morphometry were used to assess abnormalities in gray matter volumes in 23 boys ages 12 to 17 years with CD (17 comorbid for attention-deficit/hyperactivity disorder) in comparison with age- and IQ-matched controls.Compared with healthy controls, mean gray matter volume was 6% smaller in the clinical group. Compared with controls, reduced gray matter volumes were found in the left orbitofrontal region and bilaterally in the temporal lobes, including the amygdala and hippocampus on the left side in the CD group. Regression analyses in the clinical group indicated an inverse association of hyperactive/impulsive symptoms and widespread gray matter abnormalities in the frontoparietal and temporal cortices. By contrast, CD symptoms correlated primarily with gray matter reductions in limbic brain structures.The data suggest that boys with CD and comorbid attention-deficit/hyperactivity disorder show brain abnormalities in frontolimbic areas that resemble structural brain deficits, which are typically observed in adults with antisocial behavior.
KW  - Adolescent
KW  - Amygdala: pathology
KW  - Antisocial Personality Disorder: diagnosis
KW  - Antisocial Personality Disorder: physiopathology
KW  - Attention Deficit Disorder with Hyperactivity: diagnosis
KW  - Attention Deficit Disorder with Hyperactivity: physiopathology
KW  - Brain: pathology
KW  - Child
KW  - Comorbidity
KW  - Conduct Disorder: diagnosis
KW  - Conduct Disorder: physiopathology
KW  - Dominance, Cerebral: physiology
KW  - Frontal Lobe: pathology
KW  - Hippocampus: pathology
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Parahippocampal Gyrus: pathology
KW  - Parietal Lobe: pathology
KW  - Prefrontal Cortex: pathology
KW  - Risk Factors
KW  - Temporal Lobe: pathology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:18356764
UR  - <Go to ISI:>//WOS:000255261000010
DO  - DOI:10.1097/CHI.0b013e3181676545
UR  - https://juser.fz-juelich.de/record/62197
ER  -