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@ARTICLE{Huebner:62197,
      author       = {Huebner, T. and Vloet, T. D. and Marx, I. and Konrad, K.
                      and Fink, G. R. and Herpertz, S. and Herpertz-Dahlmann, B.},
      title        = {{M}orphometric brain abnormalities in boys with conduct
                      disorder},
      journal      = {Journal of the American Academy of Child and Adolescent
                      Psychiatry},
      volume       = {47},
      issn         = {0890-8567},
      address      = {Kidlington [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PreJuSER-62197},
      pages        = {540 - 547},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Children with the early-onset type of conduct disorder (CD)
                      are at high risk for developing an antisocial personality
                      disorder. Although there have been several neuroimaging
                      studies on morphometric differences in adults with
                      antisocial personality disorder, little is known about
                      structural brain aberrations in boys with CD.Magnetic
                      resonance imaging and voxel-based morphometry were used to
                      assess abnormalities in gray matter volumes in 23 boys ages
                      12 to 17 years with CD (17 comorbid for
                      attention-deficit/hyperactivity disorder) in comparison with
                      age- and IQ-matched controls.Compared with healthy controls,
                      mean gray matter volume was $6\%$ smaller in the clinical
                      group. Compared with controls, reduced gray matter volumes
                      were found in the left orbitofrontal region and bilaterally
                      in the temporal lobes, including the amygdala and
                      hippocampus on the left side in the CD group. Regression
                      analyses in the clinical group indicated an inverse
                      association of hyperactive/impulsive symptoms and widespread
                      gray matter abnormalities in the frontoparietal and temporal
                      cortices. By contrast, CD symptoms correlated primarily with
                      gray matter reductions in limbic brain structures.The data
                      suggest that boys with CD and comorbid
                      attention-deficit/hyperactivity disorder show brain
                      abnormalities in frontolimbic areas that resemble structural
                      brain deficits, which are typically observed in adults with
                      antisocial behavior.},
      keywords     = {Adolescent / Amygdala: pathology / Antisocial Personality
                      Disorder: diagnosis / Antisocial Personality Disorder:
                      physiopathology / Attention Deficit Disorder with
                      Hyperactivity: diagnosis / Attention Deficit Disorder with
                      Hyperactivity: physiopathology / Brain: pathology / Child /
                      Comorbidity / Conduct Disorder: diagnosis / Conduct
                      Disorder: physiopathology / Dominance, Cerebral: physiology
                      / Frontal Lobe: pathology / Hippocampus: pathology / Humans
                      / Image Processing, Computer-Assisted / Magnetic Resonance
                      Imaging / Male / Parahippocampal Gyrus: pathology / Parietal
                      Lobe: pathology / Prefrontal Cortex: pathology / Risk
                      Factors / Temporal Lobe: pathology / J (WoSType)},
      cin          = {INB-3 / JARA-BRAIN},
      ddc          = {150},
      cid          = {I:(DE-Juel1)INB-3-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Psychology, Developmental / Pediatrics / Psychiatry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18356764},
      UT           = {WOS:000255261000010},
      doi          = {10.1097/CHI.0b013e3181676545},
      url          = {https://juser.fz-juelich.de/record/62197},
}