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@ARTICLE{Tappe:62405,
      author       = {Tappe, W. and Zarfl, C. and Kummer, S. and Burauel, P. and
                      Vereecken, H. and Groeneweg, J.},
      title        = {{G}rowth-inhibitory effects of sulfonamides at different
                      p{H}: {D}issimilar susceptibility patterns of a soil
                      bacterium and a test bacterium used for antibiotic assays},
      journal      = {Chemosphere},
      volume       = {72},
      issn         = {0045-6535},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-62405},
      pages        = {836 - 843},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The ionic speciation of sulfonamides is pH-driven and this
                      may be crucial for their bioavailability and sorption to
                      soil constituents, as well as for their uptake into
                      bacterial cells. The inhibition behaviour of a bacterial
                      test strain (Pseudomonas aeruginosa; DSM 1117), which was
                      grown in the presence of different concentrations of 8
                      sulfonamides at pH values from 5 to 8, could be predicted by
                      models that take the speciation of sulfonamides in- and
                      outside of bacterial cells into account. Assuming a pH of
                      7.5 inside the cells (pH homeostasis), the strongest
                      inhibition was predicted for the lowest external pH and for
                      sulfonamides with the lowest pK(a) values. Growth
                      experiments with Ps. aeruginosa basically reflected this
                      predicted behaviour. However, Pantoea agglomerans -- a
                      bacterial strain isolated from arable soil -- behaved
                      surprisingly different regarding its pH dependency: all
                      sulfonamides showed the strongest effects at pH 7 to 8
                      instead of being most effective at lowest pH, although the
                      pK(a) dependencies followed the same pattern. Experimental
                      and modeling results could be brought into good agreement
                      for P. agglomerans if the cell-internal pH was admitted to
                      approximate the external pH instead of implying pH
                      homeostasis for modeling calculations. Thus, besides the
                      actual concentration of sulfonamides, the pH dependent mode
                      of reaction of different bacteria to sulfonamides may
                      additionally govern the population dynamics in soils.},
      keywords     = {Anti-Bacterial Agents: analysis / Anti-Bacterial Agents:
                      metabolism / Anti-Bacterial Agents: toxicity / Bacteria:
                      chemistry / Bacteria: drug effects / Bacteria: metabolism /
                      Biological Assay / Culture Media / Data Interpretation,
                      Statistical / Homeostasis / Hydrogen-Ion Concentration /
                      Models, Statistical / Pantoea: chemistry / Pantoea: drug
                      effects / Pantoea: metabolism / Pseudomonas aeruginosa:
                      chemistry / Pseudomonas aeruginosa: drug effects /
                      Pseudomonas aeruginosa: metabolism / Soil Microbiology /
                      Sulfonamides: analysis / Sulfonamides: metabolism /
                      Sulfonamides: toxicity / Anti-Bacterial Agents (NLM
                      Chemicals) / Culture Media (NLM Chemicals) / Sulfonamides
                      (NLM Chemicals) / J (WoSType)},
      cin          = {ICG-4 / JARA-SIM},
      ddc          = {333.7},
      cid          = {I:(DE-Juel1)VDB793 / I:(DE-Juel1)VDB1045},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      shelfmark    = {Environmental Sciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18396316},
      UT           = {WOS:000257223700021},
      doi          = {10.1016/j.chemosphere.2008.02.041},
      url          = {https://juser.fz-juelich.de/record/62405},
}