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@ARTICLE{Bailly:62894,
      author       = {Bailly, A. and Sovero, V. and Vincenzetti, V. and Santelia,
                      D. and Bartnik, D. and Koenig, B. W. and Mancuso, S. and
                      Martinoia, E. and Geisler, M.},
      title        = {{M}odulation of {P}-glycoproteins by auxin transport
                      inhibitors is mediated by interaction with immunophilins},
      journal      = {The journal of biological chemistry},
      volume       = {283},
      issn         = {0021-9258},
      address      = {Bethesda, Md.},
      publisher    = {Soc.},
      reportid     = {PreJuSER-62894},
      pages        = {21817 - 21826},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The immunophilin-like FKBP42 TWISTED DWARF1 (TWD1) has been
                      shown to control plant development via the positive
                      modulation of ABCB/P-glycoprotein (PGP)-mediated transport
                      of the plant hormone auxin. TWD1 functionally interacts with
                      two closely related proteins, ABCB1/PGP1 and
                      ABCB19/PGP19/MDR1, both of which exhibit the ability to bind
                      to and be inhibited by the synthetic auxin transport
                      inhibitor N-1-naphylphtalamic acid (NPA). They are also
                      inhibited by flavonoid compounds, which are suspected
                      modulators of auxin transport. The mechanisms by which
                      flavonoids and NPA interfere with auxin efflux components
                      are unclear. We report here the specific disruption of
                      PGP1-TWD1 interaction by NPA and flavonoids using
                      bioluminescence resonance energy transfer with flavonoids
                      functioning as a classical established inhibitor of
                      mammalian and plant PGPs. Accordingly, TWD1 was shown to
                      mediate modulation of PGP1 efflux activity by these auxin
                      transport inhibitors. NPA bound to both PGP1 and TWD1 but
                      was excluded from the PGP1-TWD1 complex expressed in yeast,
                      suggesting a transient mode of action in planta. As a
                      consequence, auxin fluxes and gravitropism in twd1 roots are
                      less affected by NPA treatment, whereas TWD1
                      gain-of-function promotes root bending. Our data support a
                      novel model for the mode of drug-mediated P-glycoprotein
                      regulation mediated via protein-protein interaction with
                      immunophilin-like TWD1.},
      keywords     = {ATP-Binding Cassette Transporters: chemistry / Arabidopsis:
                      metabolism / Arabidopsis Proteins: chemistry / Biological
                      Transport / Cell Membrane: metabolism / Flavonoids:
                      chemistry / Homozygote / Immunophilins: chemistry /
                      Indoleacetic Acids: chemistry / Luminescence / Models,
                      Biological / P-Glycoprotein: chemistry / P-Glycoproteins:
                      chemistry / Plant Roots: metabolism / Protein Binding /
                      Tacrolimus Binding Proteins: chemistry / ATP-Binding
                      Cassette Transporters (NLM Chemicals) / ATPGP1 protein,
                      Arabidopsis (NLM Chemicals) / Arabidopsis Proteins (NLM
                      Chemicals) / Flavonoids (NLM Chemicals) / Indoleacetic Acids
                      (NLM Chemicals) / P-Glycoprotein (NLM Chemicals) /
                      P-Glycoproteins (NLM Chemicals) / TWD1 protein, Arabidopsis
                      (NLM Chemicals) / Tacrolimus Binding Proteins (NLM
                      Chemicals) / Immunophilins (NLM Chemicals) / J (WoSType)},
      cin          = {INB-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB805},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Biochemistry $\&$ Molecular Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18499676},
      UT           = {WOS:000257898800055},
      doi          = {10.1074/jbc.M709655200},
      url          = {https://juser.fz-juelich.de/record/62894},
}