TY  - JOUR
AU  - Fischl, B
AU  - Rajendran, N.
AU  - Busa, E.
AU  - Augustinack, J.
AU  - Hinds, O.
AU  - Yeo, T.
AU  - Mohlberg, H.
AU  - Amunts, K.
AU  - Zilles, K.
TI  - Cortical Folding Patterns and Predicting Cytoarchitecture
JO  - Cerebral cortex
VL  - 18
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-62934
SP  - 1973 - 1980
PY  - 2008
N1  - Record converted from VDB: 12.11.2012
AB  - The human cerebral cortex is made up of a mosaic of structural areas, frequently referred to as Brodmann areas (BAs). Despite the widespread use of cortical folding patterns to perform ad hoc estimations of the locations of the BAs, little is understood regarding 1) how variable the position of a given BA is with respect to the folds, 2) whether the location of some BAs is more variable than others, and 3) whether the variability is related to the level of a BA in a putative cortical hierarchy. We use whole-brain histology of 10 postmortem human brains and surface-based analysis to test how well the folds predict the locations of the BAs. We show that higher order cortical areas exhibit more variability than primary and secondary areas and that the folds are much better predictors of the BAs than had been previously thought. These results further highlight the significance of cortical folding patterns and suggest a common mechanism for the development of the folds and the cytoarchitectonic fields.
KW  - Brain Mapping: methods
KW  - Cerebral Cortex: cytology
KW  - Cerebral Cortex: physiology
KW  - Humans
KW  - Predictive Value of Tests
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:18079129
C2  - pmc:PMC2474454
UR  - <Go to ISI:>//WOS:000257787300023
DO  - DOI:10.1093/cercor/bhm225
UR  - https://juser.fz-juelich.de/record/62934
ER  -