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000062951 0247_ $$2DOI$$a10.1111/j.1469-7610.2008.01905.x
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000062951 084__ $$2WoS$$aPsychology, Developmental
000062951 084__ $$2WoS$$aPsychiatry
000062951 084__ $$2WoS$$aPsychology
000062951 1001_ $$0P:(DE-HGF)0$$aHerpertz, S. C.$$b0
000062951 245__ $$aEmotional processing in male adolescents with childhood-onset conduct disorder
000062951 260__ $$aMalden$$bBlackwell Publishing Limited$$c2008
000062951 300__ $$a781 - 791
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000062951 440_0 $$018261$$aJournal of Child Psychology and Psychiatry$$v49$$x0021-9630$$y7
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000062951 520__ $$aBoys with early onset of conduct disorder (CD), most of whom also meet diagnostic criteria of a comorbid attention deficit hyperactivity disorder (ADHD), tend to exhibit high levels of aggression throughout development. While a number of functional neuroimaging studies on emotional processing have been performed in antisocial adults, little is known about how CD children process emotional information.Functional magnetic resonance imaging data were analyzed in 22 male adolescents aged 12 to 17 years with childhood-onset CD (16 of them with comorbid ADHD) compared to 22 age-matched male healthy controls. In order to consider the likely confounding of results through ADHD comorbidity, we performed a supplementary study including 13 adolescent subjects with pure ADHD who were compared with healthy controls. To challenge emotional processing of stimuli, a passive viewing task was applied, presenting pictures of negative, positive or neutral valence.When comparing CD/combined disorder patients with healthy controls, we found enhanced left-sided amygdala activation in response to negative pictures as compared to neutral pictures in the patient group. In addition, these boys exhibited no reduced activation in the orbitofrontal, anterior cingulate and insular cortices. By contrast, children with pure ADHD did not show any abnormalities in amygdala activation but showed decreased neural activity in the insula only in response to negative pictures.Increased rather than reduced amygdala activation found in our study may indicate an enhanced response to environmental cues in adolescents with early-onset CD (most of whom also met the condition of ADHD), and is not consistent with the assumption of a reduced capacity to take note of affective information in the social environment. Further studies with an emphasis on developmental aspects of affect regulation are needed to clarify the relationship between CD and adult personality pathology associated with different modes of persistent antisocial behavior.
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000062951 650_2 $$2MeSH$$aAdolescent
000062951 650_2 $$2MeSH$$aAggression: physiology
000062951 650_2 $$2MeSH$$aAggression: psychology
000062951 650_2 $$2MeSH$$aAmygdala: physiopathology
000062951 650_2 $$2MeSH$$aArousal: physiology
000062951 650_2 $$2MeSH$$aAttention Deficit Disorder with Hyperactivity: diagnosis
000062951 650_2 $$2MeSH$$aAttention Deficit Disorder with Hyperactivity: physiopathology
000062951 650_2 $$2MeSH$$aAttention Deficit Disorder with Hyperactivity: psychology
000062951 650_2 $$2MeSH$$aBrain Mapping
000062951 650_2 $$2MeSH$$aCerebral Cortex: physiopathology
000062951 650_2 $$2MeSH$$aChild
000062951 650_2 $$2MeSH$$aComorbidity
000062951 650_2 $$2MeSH$$aConduct Disorder: diagnosis
000062951 650_2 $$2MeSH$$aConduct Disorder: physiopathology
000062951 650_2 $$2MeSH$$aConduct Disorder: psychology
000062951 650_2 $$2MeSH$$aDominance, Cerebral: physiology
000062951 650_2 $$2MeSH$$aEmotions: physiology
000062951 650_2 $$2MeSH$$aHumans
000062951 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000062951 650_2 $$2MeSH$$aMale
000062951 650_2 $$2MeSH$$aPersonality Inventory
000062951 650_2 $$2MeSH$$aReference Values
000062951 650_2 $$2MeSH$$aVisual Perception: physiology
000062951 650_7 $$2WoSType$$aJ
000062951 65320 $$2Author$$aconduct disorder
000062951 65320 $$2Author$$afMRI
000062951 65320 $$2Author$$aemotion
000062951 65320 $$2Author$$aantisocial behavior
000062951 65320 $$2Author$$aamygdala
000062951 65320 $$2Author$$aantisocial personality disorder
000062951 7001_ $$0P:(DE-HGF)0$$aHuebner, T.$$b1
000062951 7001_ $$0P:(DE-HGF)0$$aMarx, I.$$b2
000062951 7001_ $$0P:(DE-HGF)0$$aVloet, T. D.$$b3
000062951 7001_ $$0P:(DE-Juel1)131720$$aFink, G. R.$$b4$$uFZJ
000062951 7001_ $$0P:(DE-Juel1)VDB30236$$aStoecker, T.$$b5$$uFZJ
000062951 7001_ $$0P:(DE-Juel1)131794$$aShah, J. N.$$b6$$uFZJ
000062951 7001_ $$0P:(DE-HGF)0$$aKonrad, K.$$b7
000062951 7001_ $$0P:(DE-HGF)0$$aHerpertz-Dahlmann, B.$$b8
000062951 773__ $$0PERI:(DE-600)2255259-5$$a10.1111/j.1469-7610.2008.01905.x$$gVol. 49, p. 781 - 791$$p781 - 791$$q49<781 - 791$$tJournal of Child Psychology and Psychiatry$$v49$$x0021-9630$$y2008
000062951 8567_ $$uhttp://dx.doi.org/10.1111/j.1469-7610.2008.01905.x
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