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@ARTICLE{Herpertz:62951,
      author       = {Herpertz, S. C. and Huebner, T. and Marx, I. and Vloet, T.
                      D. and Fink, G. R. and Stoecker, T. and Shah, J. N. and
                      Konrad, K. and Herpertz-Dahlmann, B.},
      title        = {{E}motional processing in male adolescents with
                      childhood-onset conduct disorder},
      journal      = {Journal of Child Psychology and Psychiatry},
      volume       = {49},
      issn         = {0021-9630},
      address      = {Malden},
      publisher    = {Blackwell Publishing Limited},
      reportid     = {PreJuSER-62951},
      pages        = {781 - 791},
      year         = {2008},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Boys with early onset of conduct disorder (CD), most of
                      whom also meet diagnostic criteria of a comorbid attention
                      deficit hyperactivity disorder (ADHD), tend to exhibit high
                      levels of aggression throughout development. While a number
                      of functional neuroimaging studies on emotional processing
                      have been performed in antisocial adults, little is known
                      about how CD children process emotional
                      information.Functional magnetic resonance imaging data were
                      analyzed in 22 male adolescents aged 12 to 17 years with
                      childhood-onset CD (16 of them with comorbid ADHD) compared
                      to 22 age-matched male healthy controls. In order to
                      consider the likely confounding of results through ADHD
                      comorbidity, we performed a supplementary study including 13
                      adolescent subjects with pure ADHD who were compared with
                      healthy controls. To challenge emotional processing of
                      stimuli, a passive viewing task was applied, presenting
                      pictures of negative, positive or neutral valence.When
                      comparing CD/combined disorder patients with healthy
                      controls, we found enhanced left-sided amygdala activation
                      in response to negative pictures as compared to neutral
                      pictures in the patient group. In addition, these boys
                      exhibited no reduced activation in the orbitofrontal,
                      anterior cingulate and insular cortices. By contrast,
                      children with pure ADHD did not show any abnormalities in
                      amygdala activation but showed decreased neural activity in
                      the insula only in response to negative pictures.Increased
                      rather than reduced amygdala activation found in our study
                      may indicate an enhanced response to environmental cues in
                      adolescents with early-onset CD (most of whom also met the
                      condition of ADHD), and is not consistent with the
                      assumption of a reduced capacity to take note of affective
                      information in the social environment. Further studies with
                      an emphasis on developmental aspects of affect regulation
                      are needed to clarify the relationship between CD and adult
                      personality pathology associated with different modes of
                      persistent antisocial behavior.},
      keywords     = {Adolescent / Aggression: physiology / Aggression:
                      psychology / Amygdala: physiopathology / Arousal: physiology
                      / Attention Deficit Disorder with Hyperactivity: diagnosis /
                      Attention Deficit Disorder with Hyperactivity:
                      physiopathology / Attention Deficit Disorder with
                      Hyperactivity: psychology / Brain Mapping / Cerebral Cortex:
                      physiopathology / Child / Comorbidity / Conduct Disorder:
                      diagnosis / Conduct Disorder: physiopathology / Conduct
                      Disorder: psychology / Dominance, Cerebral: physiology /
                      Emotions: physiology / Humans / Magnetic Resonance Imaging /
                      Male / Personality Inventory / Reference Values / Visual
                      Perception: physiology / J (WoSType)},
      cin          = {INB-3 / JARA-BRAIN},
      ddc          = {050},
      cid          = {I:(DE-Juel1)INB-3-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Psychology, Developmental / Psychiatry / Psychology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18598245},
      UT           = {WOS:000256855000012},
      doi          = {10.1111/j.1469-7610.2008.01905.x},
      url          = {https://juser.fz-juelich.de/record/62951},
}