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024 7 _ |2 pmid
|a pmid:18598245
024 7 _ |2 DOI
|a 10.1111/j.1469-7610.2008.01905.x
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|a WOS:000256855000012
024 7 _ |a 0021-9630
|2 ISSN
037 _ _ |a PreJuSER-62951
041 _ _ |a eng
082 _ _ |a 050
084 _ _ |2 WoS
|a Psychology, Developmental
084 _ _ |2 WoS
|a Psychiatry
084 _ _ |2 WoS
|a Psychology
100 1 _ |a Herpertz, S. C.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Emotional processing in male adolescents with childhood-onset conduct disorder
260 _ _ |c 2008
|a Malden
|b Blackwell Publishing Limited
300 _ _ |a 781 - 791
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |a Journal of Child Psychology and Psychiatry
|x 0021-9630
|0 18261
|y 7
|v 49
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Boys with early onset of conduct disorder (CD), most of whom also meet diagnostic criteria of a comorbid attention deficit hyperactivity disorder (ADHD), tend to exhibit high levels of aggression throughout development. While a number of functional neuroimaging studies on emotional processing have been performed in antisocial adults, little is known about how CD children process emotional information.Functional magnetic resonance imaging data were analyzed in 22 male adolescents aged 12 to 17 years with childhood-onset CD (16 of them with comorbid ADHD) compared to 22 age-matched male healthy controls. In order to consider the likely confounding of results through ADHD comorbidity, we performed a supplementary study including 13 adolescent subjects with pure ADHD who were compared with healthy controls. To challenge emotional processing of stimuli, a passive viewing task was applied, presenting pictures of negative, positive or neutral valence.When comparing CD/combined disorder patients with healthy controls, we found enhanced left-sided amygdala activation in response to negative pictures as compared to neutral pictures in the patient group. In addition, these boys exhibited no reduced activation in the orbitofrontal, anterior cingulate and insular cortices. By contrast, children with pure ADHD did not show any abnormalities in amygdala activation but showed decreased neural activity in the insula only in response to negative pictures.Increased rather than reduced amygdala activation found in our study may indicate an enhanced response to environmental cues in adolescents with early-onset CD (most of whom also met the condition of ADHD), and is not consistent with the assumption of a reduced capacity to take note of affective information in the social environment. Further studies with an emphasis on developmental aspects of affect regulation are needed to clarify the relationship between CD and adult personality pathology associated with different modes of persistent antisocial behavior.
536 _ _ |a Funktion und Dysfunktion des Nervensystems
|c P33
|2 G:(DE-HGF)
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Adolescent
650 _ 2 |2 MeSH
|a Aggression: physiology
650 _ 2 |2 MeSH
|a Aggression: psychology
650 _ 2 |2 MeSH
|a Amygdala: physiopathology
650 _ 2 |2 MeSH
|a Arousal: physiology
650 _ 2 |2 MeSH
|a Attention Deficit Disorder with Hyperactivity: diagnosis
650 _ 2 |2 MeSH
|a Attention Deficit Disorder with Hyperactivity: physiopathology
650 _ 2 |2 MeSH
|a Attention Deficit Disorder with Hyperactivity: psychology
650 _ 2 |2 MeSH
|a Brain Mapping
650 _ 2 |2 MeSH
|a Cerebral Cortex: physiopathology
650 _ 2 |2 MeSH
|a Child
650 _ 2 |2 MeSH
|a Comorbidity
650 _ 2 |2 MeSH
|a Conduct Disorder: diagnosis
650 _ 2 |2 MeSH
|a Conduct Disorder: physiopathology
650 _ 2 |2 MeSH
|a Conduct Disorder: psychology
650 _ 2 |2 MeSH
|a Dominance, Cerebral: physiology
650 _ 2 |2 MeSH
|a Emotions: physiology
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Personality Inventory
650 _ 2 |2 MeSH
|a Reference Values
650 _ 2 |2 MeSH
|a Visual Perception: physiology
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a conduct disorder
653 2 0 |2 Author
|a fMRI
653 2 0 |2 Author
|a emotion
653 2 0 |2 Author
|a antisocial behavior
653 2 0 |2 Author
|a amygdala
653 2 0 |2 Author
|a antisocial personality disorder
700 1 _ |a Huebner, T.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Marx, I.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Vloet, T. D.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Fink, G. R.
|b 4
|u FZJ
|0 P:(DE-Juel1)131720
700 1 _ |a Stoecker, T.
|b 5
|u FZJ
|0 P:(DE-Juel1)VDB30236
700 1 _ |a Shah, J. N.
|b 6
|u FZJ
|0 P:(DE-Juel1)131794
700 1 _ |a Konrad, K.
|b 7
|0 P:(DE-HGF)0
700 1 _ |a Herpertz-Dahlmann, B.
|b 8
|0 P:(DE-HGF)0
773 _ _ |0 PERI:(DE-600)2255259-5
|a 10.1111/j.1469-7610.2008.01905.x
|g Vol. 49, p. 781 - 791
|p 781 - 791
|q 49<781 - 791
|t Journal of Child Psychology and Psychiatry
|v 49
|x 0021-9630
|y 2008
856 7 _ |u http://dx.doi.org/10.1111/j.1469-7610.2008.01905.x
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