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000007023 0247_ $$2pmid$$apmid:19923283
000007023 0247_ $$2pmc$$apmc:PMC2820256
000007023 0247_ $$2DOI$$a10.1523/JNEUROSCI.4004-09.2009
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000007023 041__ $$aeng
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000007023 084__ $$2WoS$$aNeurosciences
000007023 1001_ $$0P:(DE-HGF)0$$aLaird, A.R.$$b0
000007023 245__ $$aInvestigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling
000007023 260__ $$aWashington, DC$$bSoc.$$c2009
000007023 300__ $$a14496 - 14505
000007023 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000007023 3367_ $$2BibTeX$$aARTICLE
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000007023 3367_ $$2DRIVER$$aarticle
000007023 440_0 $$03603$$aJournal of Neuroscience$$v29$$x0270-6474$$y46
000007023 500__ $$aThis work was supported by the National Institute of Mental Health ( Grants R01-MH074457 to P. T. F. and R01-MH084812 to A. R. L.), the Department of Defense (STRONGSTAR Neuroimaging Core to P. T. F.), and the Helmholz Initiative on Systems-Biology ( S. B. E.). Special thanks to Reese McKay for his input and to Steve Smith, Donald Dudley, and Robert Huff for insightful discussions.
000007023 520__ $$aThe default mode network (DMN) comprises a set of regions that exhibit ongoing, intrinsic activity in the resting state and task-related decreases in activity across a range of paradigms. However, DMN regions have also been reported as task-related increases, either independently or coactivated with other regions in the network. Cognitive subtractions and the use of low-level baseline conditions have generally masked the functional nature of these regions. Using a combination of activation likelihood estimation, which assesses statistically significant convergence of neuroimaging results, and tools distributed with the BrainMap database, we identified core regions in the DMN and examined their functional heterogeneity. Meta-analytic coactivation maps of task-related increases were independently generated for each region, which included both within-DMN and non-DMN connections. Their functional properties were assessed using behavioral domain metadata in BrainMap. These results were integrated to determine a DMN connectivity model that represents the patterns of interactions observed in task-related increases in activity across diverse tasks. Subnetwork components of this model were identified, and behavioral domain analysis of these cliques yielded discrete functional properties, demonstrating that components of the DMN are differentially specialized. Affective and perceptual cliques of the DMN were identified, as well as the cliques associated with a reduced preference for motor processing. In summary, we used advanced coordinate-based meta-analysis techniques to explicate behavior and connectivity in the default mode network; future work will involve applying this analysis strategy to other modes of brain function, such as executive function or sensorimotor systems.
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000007023 588__ $$aDataset connected to Web of Science, Pubmed
000007023 650_2 $$2MeSH$$aBrain: physiology
000007023 650_2 $$2MeSH$$aBrain Mapping: methods
000007023 650_2 $$2MeSH$$aBrain Mapping: standards
000007023 650_2 $$2MeSH$$aDatabases, Factual: standards
000007023 650_2 $$2MeSH$$aHumans
000007023 650_2 $$2MeSH$$aMeta-Analysis as Topic
000007023 650_2 $$2MeSH$$aNerve Net: physiology
000007023 650_2 $$2MeSH$$aNeural Networks (Computer)
000007023 650_7 $$2WoSType$$aJ
000007023 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b1$$uFZJ
000007023 7001_ $$0P:(DE-HGF)0$$aLi, K.$$b2
000007023 7001_ $$0P:(DE-HGF)0$$aRobin, D.A.$$b3
000007023 7001_ $$0P:(DE-HGF)0$$aGlahn, D.C.$$b4
000007023 7001_ $$0P:(DE-HGF)0$$aFox, P.T.$$b5
000007023 773__ $$0PERI:(DE-600)1475274-8$$a10.1523/JNEUROSCI.4004-09.2009$$gVol. 29, p. 14496 - 14505$$p14496 - 14505$$q29<14496 - 14505$$tThe @journal of neuroscience$$v29$$x0270-6474$$y2009
000007023 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820256
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