TY  - JOUR
AU  - Wu, S.S.
AU  - Chang, T.T.
AU  - Majid, A.
AU  - Caspers, S.
AU  - Eickhoff, S. B.
AU  - Menon, V.
TI  - Functional Heterogeneity of Inferior Parietal Cortex during Mathematical Cognition Assessed with Cytoarchitectonic Probability Maps
JO  - Cerebral cortex
VL  - 19
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-7024
SP  - 2930 - 2945
PY  - 2009
N1  - National Institutes of Health (HD047520 and HD059205) and the National Science Foundation (BCS/DRL-0750340).
AB  - Although the inferior parietal cortex (IPC) has been consistently implicated in mathematical cognition, the functional roles of its subdivisions are poorly understood. We address this problem using probabilistic cytoarchitectonic maps of IPC subdivisions intraparietal sulcus (IPS), angular gyrus (AG), and supramarginal gyrus. We quantified IPC responses relative to task difficulty and individual differences in task proficiency during mental arithmetic (MA) tasks performed with Arabic (MA-A) and Roman (MA-R) numerals. The 2 tasks showed similar levels of activation in 3 distinct IPS areas, hIP1, hIP2, and hIP3, suggesting their obligatory role in MA. Both AG areas, PGa and PGp, were strongly deactivated in both tasks, with stronger deactivations in posterior area PGp. Compared with the more difficult MA-R task, the MA-A task showed greater responses in both AG areas, but this effect was driven by less deactivation in the MA-A task. AG deactivations showed prominent overlap with lateral parietal nodes of the default mode network, suggesting a nonspecific role in MA. In both tasks, greater bilateral AG deactivation was associated with poorer performance. Our findings suggest a close link between IPC structure and function and they provide new evidence for behaviorally salient functional heterogeneity within the IPC during mathematical cognition.
KW  - Adolescent
KW  - Adult
KW  - Brain Mapping
KW  - Cognition: physiology
KW  - Female
KW  - Humans
KW  - Male
KW  - Mathematics
KW  - Models, Neurological
KW  - Models, Statistical
KW  - Parietal Lobe: physiology
KW  - Problem Solving: physiology
KW  - Young Adult
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19406903
C2  - pmc:PMC2774395
UR  - <Go to ISI:>//WOS:000271813900013
DO  - DOI:10.1093/cercor/bhp063
UR  - https://juser.fz-juelich.de/record/7024
ER  -