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000007995 0247_ $$2DOI$$a10.1016/j.jasms.2009.09.022
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000007995 084__ $$2WoS$$aBiochemical Research Methods
000007995 084__ $$2WoS$$aChemistry, Analytical
000007995 084__ $$2WoS$$aChemistry, Physical
000007995 084__ $$2WoS$$aSpectroscopy
000007995 1001_ $$0P:(DE-Juel1)138474$$aMatusch, A.$$b0$$uFZJ
000007995 245__ $$aCerebral Bioimaing of Cu, Fe, Zn, and Mn in the MPTP Mouse Model of Parkinson’s Disease Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS)
000007995 260__ $$aNew York [u.a.]$$bSpringer$$c2010
000007995 300__ $$a161 - 171
000007995 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000007995 440_0 $$020622$$aJournal of The American Society for Mass Spectrometry$$v21$$x1044-0305$$y1
000007995 500__ $$aThe authors thank A. Zimmermann (Forschungszentrum Julich) for technical support with LA-ICP-MS measurements. This study was supported in part by the German Parkinson's Society and the University Hospitals of Giessen and Marburg, Germany.
000007995 520__ $$aLaser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been established as a powerful technique for the determination of metal and nonmetal distributions within biological systems with high sensitivity. An imaging LA-ICP-MS technique for Fe, Cu, Zn, and Mn was developed to produce large series of quantitative element maps in native brain sections of mice subchronically intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) as a model of Parkinson's disease. Images were calibrated using matrix-matched laboratory standards. A software solution allowing a precise delineation of anatomical structures was implemented. Coronal brain sections were analyzed crossing the striatum and the substantia nigra, respectively. Animals sacrificed 2 h, 7 d, or 28 d after the last MPTP injection and controls were investigated. We observed significant decreases of Cu concentrations in the periventricular zone and the fascia dentata at 2 h and 7d and a recovery or overcompensation at 28 d, most pronounced in the rostral periventricular zone (+40%). In the cortex Cu decreased slightly to -10%. Fe increased in the interpeduncular nucleus (+40%) but not in the substantia nigra. This pattern is in line with a differential regulation of periventricular and parenchymal Cu, and with the histochemical localization of Fe, and congruent to regions of preferential MPTP binding described in the rodent brain. The LA-ICP-MS technique yielded valid and statistically robust results in the present study on 39 slices from 19 animals. Our findings underline the value of routine micro-local analytical techniques in the life sciences and affirm a role of Cu availability in Parkinson's disease.
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000007995 650_2 $$2MeSH$$a1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: pharmacology
000007995 650_2 $$2MeSH$$aAnimals
000007995 650_2 $$2MeSH$$aBrain: drug effects
000007995 650_2 $$2MeSH$$aBrain: pathology
000007995 650_2 $$2MeSH$$aBrain Chemistry
000007995 650_2 $$2MeSH$$aCalibration
000007995 650_2 $$2MeSH$$aCopper: analysis
000007995 650_2 $$2MeSH$$aEquipment Design
000007995 650_2 $$2MeSH$$aIron: analysis
000007995 650_2 $$2MeSH$$aLaser Therapy
000007995 650_2 $$2MeSH$$aMale
000007995 650_2 $$2MeSH$$aManganese: analysis
000007995 650_2 $$2MeSH$$aMass Spectrometry: instrumentation
000007995 650_2 $$2MeSH$$aMass Spectrometry: methods
000007995 650_2 $$2MeSH$$aMetals, Heavy: analysis
000007995 650_2 $$2MeSH$$aMice
000007995 650_2 $$2MeSH$$aMice, Inbred C57BL
000007995 650_2 $$2MeSH$$aNeurotoxins: pharmacology
000007995 650_2 $$2MeSH$$aParkinson Disease: metabolism
000007995 650_2 $$2MeSH$$aZinc: analysis
000007995 650_7 $$00$$2NLM Chemicals$$aMetals, Heavy
000007995 650_7 $$00$$2NLM Chemicals$$aNeurotoxins
000007995 650_7 $$028289-54-5$$2NLM Chemicals$$a1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
000007995 650_7 $$07439-89-6$$2NLM Chemicals$$aIron
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000007995 650_7 $$07440-50-8$$2NLM Chemicals$$aCopper
000007995 650_7 $$07440-66-6$$2NLM Chemicals$$aZinc
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000007995 7001_ $$0P:(DE-Juel1)138881$$aWu, B.$$b3$$uFZJ
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000007995 7001_ $$0P:(DE-Juel1)VDB2662$$aBecker, J. S.$$b6$$uFZJ
000007995 773__ $$0PERI:(DE-600)2019911-9$$a10.1016/j.jasms.2009.09.022$$gVol. 21, p. 161 - 171$$p161 - 171$$q21<161 - 171$$tJournal of the American Society for Mass Spectrometry$$v21$$x1044-0305$$y2010
000007995 8567_ $$uhttp://dx.doi.org/10.1016/j.jasms.2009.09.022
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