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@ARTICLE{Matusch:7995,
      author       = {Matusch, A. and Depboylu, C. and Palm, C. and Wu, B. and
                      Höglinger, G.U. and Schäfer, M.K.-H. and Becker, J. S.},
      title        = {{C}erebral {B}ioimaing of {C}u, {F}e, {Z}n, and {M}n in the
                      {MPTP} {M}ouse {M}odel of ${P}arkinson\’s$ {D}isease
                      {U}sing {L}aser {A}blation {I}nductively {C}oupled {P}lasma
                      {M}ass {S}pectrometry ({LA}-{ICP}-{MS})},
      journal      = {Journal of the American Society for Mass Spectrometry},
      volume       = {21},
      issn         = {1044-0305},
      address      = {New York [u.a.]},
      publisher    = {Springer},
      reportid     = {PreJuSER-7995},
      pages        = {161 - 171},
      year         = {2010},
      note         = {The authors thank A. Zimmermann (Forschungszentrum Julich)
                      for technical support with LA-ICP-MS measurements. This
                      study was supported in part by the German Parkinson's
                      Society and the University Hospitals of Giessen and Marburg,
                      Germany.},
      abstract     = {Laser ablation inductively coupled plasma mass spectrometry
                      (LA-ICP-MS) has been established as a powerful technique for
                      the determination of metal and nonmetal distributions within
                      biological systems with high sensitivity. An imaging
                      LA-ICP-MS technique for Fe, Cu, Zn, and Mn was developed to
                      produce large series of quantitative element maps in native
                      brain sections of mice subchronically intoxicated with
                      1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) as a
                      model of Parkinson's disease. Images were calibrated using
                      matrix-matched laboratory standards. A software solution
                      allowing a precise delineation of anatomical structures was
                      implemented. Coronal brain sections were analyzed crossing
                      the striatum and the substantia nigra, respectively. Animals
                      sacrificed 2 h, 7 d, or 28 d after the last MPTP injection
                      and controls were investigated. We observed significant
                      decreases of Cu concentrations in the periventricular zone
                      and the fascia dentata at 2 h and 7d and a recovery or
                      overcompensation at 28 d, most pronounced in the rostral
                      periventricular zone $(+40\%).$ In the cortex Cu decreased
                      slightly to $-10\%.$ Fe increased in the interpeduncular
                      nucleus $(+40\%)$ but not in the substantia nigra. This
                      pattern is in line with a differential regulation of
                      periventricular and parenchymal Cu, and with the
                      histochemical localization of Fe, and congruent to regions
                      of preferential MPTP binding described in the rodent brain.
                      The LA-ICP-MS technique yielded valid and statistically
                      robust results in the present study on 39 slices from 19
                      animals. Our findings underline the value of routine
                      micro-local analytical techniques in the life sciences and
                      affirm a role of Cu availability in Parkinson's disease.},
      keywords     = {1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: pharmacology
                      / Animals / Brain: drug effects / Brain: pathology / Brain
                      Chemistry / Calibration / Copper: analysis / Equipment
                      Design / Iron: analysis / Laser Therapy / Male / Manganese:
                      analysis / Mass Spectrometry: instrumentation / Mass
                      Spectrometry: methods / Metals, Heavy: analysis / Mice /
                      Mice, Inbred C57BL / Neurotoxins: pharmacology / Parkinson
                      Disease: metabolism / Zinc: analysis / Metals, Heavy (NLM
                      Chemicals) / Neurotoxins (NLM Chemicals) /
                      1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NLM Chemicals)
                      / Iron (NLM Chemicals) / Manganese (NLM Chemicals) / Copper
                      (NLM Chemicals) / Zinc (NLM Chemicals) / J (WoSType)},
      cin          = {ZCH / INM-1 / INM-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ZCH-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89572},
      shelfmark    = {Biochemical Research Methods / Chemistry, Analytical /
                      Chemistry, Physical / Spectroscopy},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19892565},
      UT           = {WOS:000274518100021},
      doi          = {10.1016/j.jasms.2009.09.022},
      url          = {https://juser.fz-juelich.de/record/7995},
}