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| 024 | 7 | _ | |2 pmid |a pmid:19892565 |
| 024 | 7 | _ | |2 DOI |a 10.1016/j.jasms.2009.09.022 |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 530 |
| 084 | _ | _ | |2 WoS |a Biochemical Research Methods |
| 084 | _ | _ | |2 WoS |a Chemistry, Analytical |
| 084 | _ | _ | |2 WoS |a Chemistry, Physical |
| 084 | _ | _ | |2 WoS |a Spectroscopy |
| 100 | 1 | _ | |a Matusch, A. |b 0 |u FZJ |0 P:(DE-Juel1)138474 |
| 245 | _ | _ | |a Cerebral Bioimaing of Cu, Fe, Zn, and Mn in the MPTP Mouse Model of Parkinson’s Disease Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) |
| 260 | _ | _ | |a New York [u.a.] |b Springer |c 2010 |
| 300 | _ | _ | |a 161 - 171 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a Journal of The American Society for Mass Spectrometry |x 1044-0305 |0 20622 |y 1 |v 21 |
| 500 | _ | _ | |a The authors thank A. Zimmermann (Forschungszentrum Julich) for technical support with LA-ICP-MS measurements. This study was supported in part by the German Parkinson's Society and the University Hospitals of Giessen and Marburg, Germany. |
| 520 | _ | _ | |a Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been established as a powerful technique for the determination of metal and nonmetal distributions within biological systems with high sensitivity. An imaging LA-ICP-MS technique for Fe, Cu, Zn, and Mn was developed to produce large series of quantitative element maps in native brain sections of mice subchronically intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) as a model of Parkinson's disease. Images were calibrated using matrix-matched laboratory standards. A software solution allowing a precise delineation of anatomical structures was implemented. Coronal brain sections were analyzed crossing the striatum and the substantia nigra, respectively. Animals sacrificed 2 h, 7 d, or 28 d after the last MPTP injection and controls were investigated. We observed significant decreases of Cu concentrations in the periventricular zone and the fascia dentata at 2 h and 7d and a recovery or overcompensation at 28 d, most pronounced in the rostral periventricular zone (+40%). In the cortex Cu decreased slightly to -10%. Fe increased in the interpeduncular nucleus (+40%) but not in the substantia nigra. This pattern is in line with a differential regulation of periventricular and parenchymal Cu, and with the histochemical localization of Fe, and congruent to regions of preferential MPTP binding described in the rodent brain. The LA-ICP-MS technique yielded valid and statistically robust results in the present study on 39 slices from 19 animals. Our findings underline the value of routine micro-local analytical techniques in the life sciences and affirm a role of Cu availability in Parkinson's disease. |
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| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Animals |
| 650 | _ | 2 | |2 MeSH |a Brain: drug effects |
| 650 | _ | 2 | |2 MeSH |a Brain: pathology |
| 650 | _ | 2 | |2 MeSH |a Brain Chemistry |
| 650 | _ | 2 | |2 MeSH |a Calibration |
| 650 | _ | 2 | |2 MeSH |a Copper: analysis |
| 650 | _ | 2 | |2 MeSH |a Equipment Design |
| 650 | _ | 2 | |2 MeSH |a Iron: analysis |
| 650 | _ | 2 | |2 MeSH |a Laser Therapy |
| 650 | _ | 2 | |2 MeSH |a Male |
| 650 | _ | 2 | |2 MeSH |a Manganese: analysis |
| 650 | _ | 2 | |2 MeSH |a Mass Spectrometry: instrumentation |
| 650 | _ | 2 | |2 MeSH |a Mass Spectrometry: methods |
| 650 | _ | 2 | |2 MeSH |a Metals, Heavy: analysis |
| 650 | _ | 2 | |2 MeSH |a Mice |
| 650 | _ | 2 | |2 MeSH |a Mice, Inbred C57BL |
| 650 | _ | 2 | |2 MeSH |a Neurotoxins: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Parkinson Disease: metabolism |
| 650 | _ | 2 | |2 MeSH |a Zinc: analysis |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Metals, Heavy |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Neurotoxins |
| 650 | _ | 7 | |0 28289-54-5 |2 NLM Chemicals |a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine |
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| 650 | _ | 7 | |0 7440-50-8 |2 NLM Chemicals |a Copper |
| 650 | _ | 7 | |0 7440-66-6 |2 NLM Chemicals |a Zinc |
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| 700 | 1 | _ | |a Depboylu, C. |b 1 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Palm, C. |b 2 |u FZJ |0 P:(DE-Juel1)VDB1883 |
| 700 | 1 | _ | |a Wu, B. |b 3 |u FZJ |0 P:(DE-Juel1)138881 |
| 700 | 1 | _ | |a Höglinger, G.U. |b 4 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Schäfer, M.K.-H. |b 5 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Becker, J. S. |b 6 |u FZJ |0 P:(DE-Juel1)VDB2662 |
| 773 | _ | _ | |a 10.1016/j.jasms.2009.09.022 |g Vol. 21, p. 161 - 171 |p 161 - 171 |q 21<161 - 171 |0 PERI:(DE-600)2019911-9 |t Journal of the American Society for Mass Spectrometry |v 21 |y 2010 |x 1044-0305 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1016/j.jasms.2009.09.022 |
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| 914 | 1 | _ | |y 2010 |
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