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000008020 0247_ $$2DOI$$a10.1002/mas.20239
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000008020 084__ $$2WoS$$aSpectroscopy
000008020 1001_ $$0P:(DE-Juel1)VDB2662$$aBecker, J. S.$$b0$$uFZJ
000008020 245__ $$aBioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
000008020 260__ $$aNew York, NY [u.a.]$$bWiley$$c2010
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000008020 440_0 $$021761$$aMass Spectrometry Reviews$$v29$$x0277-7037$$y1
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000008020 520__ $$aThe distribution analysis of (essential, beneficial, or toxic) metals (e.g., Cu, Fe, Zn, Pb, and others), metalloids, and non-metals in biological tissues is of key interest in life science. Over the past few years, the development and application of several imaging mass spectrometric techniques has been rapidly growing in biology and medicine. Especially, in brain research metalloproteins are in the focus of targeted therapy approaches of neurodegenerative diseases such as Alzheimer's and Parkinson's disease, or stroke, or tumor growth. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) using double-focusing sector field (LA-ICP-SFMS) or quadrupole-based mass spectrometers (LA-ICP-QMS) has been successfully applied as a powerful imaging (mapping) technique to produce quantitative images of detailed regionally specific element distributions in thin tissue sections of human or rodent brain. Imaging LA-ICP-QMS was also applied to investigate metal distributions in plant and animal sections to study, for example, the uptake and transport of nutrient and toxic elements or environmental contamination. The combination of imaging LA-ICP-MS of metals with proteomic studies using biomolecular mass spectrometry identifies metal-containing proteins and also phosphoproteins. Metal-containing proteins were imaged in a two-dimensional gel after electrophoretic separation of proteins (SDS or Blue Native PAGE). Recent progress in LA-ICP-MS imaging as a stand-alone technique and in combination with MALDI/ESI-MS for selected life science applications is summarized.
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000008020 650_2 $$2MeSH$$aAnimals
000008020 650_2 $$2MeSH$$aBrain Chemistry
000008020 650_2 $$2MeSH$$aEquipment Design
000008020 650_2 $$2MeSH$$aHumans
000008020 650_2 $$2MeSH$$aLaser Therapy: instrumentation
000008020 650_2 $$2MeSH$$aLaser Therapy: methods
000008020 650_2 $$2MeSH$$aLaser Therapy: trends
000008020 650_2 $$2MeSH$$aMass Spectrometry: instrumentation
000008020 650_2 $$2MeSH$$aMass Spectrometry: methods
000008020 650_2 $$2MeSH$$aMass Spectrometry: trends
000008020 650_2 $$2MeSH$$aMetals: analysis
000008020 650_2 $$2MeSH$$aNeurodegenerative Diseases: pathology
000008020 650_2 $$2MeSH$$aPlants: chemistry
000008020 650_7 $$00$$2NLM Chemicals$$aMetals
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000008020 65320 $$2Author$$abioimaging of metals
000008020 65320 $$2Author$$alaser ablation inductively coupled plasma mass spectrometry
000008020 65320 $$2Author$$ametal distribution
000008020 65320 $$2Author$$ametal-lomics
000008020 65320 $$2Author$$aneurodegenerative diseases
000008020 7001_ $$0P:(DE-Juel1)VDB25017$$aZoriy, M.$$b1$$uFZJ
000008020 7001_ $$0P:(DE-Juel1)138474$$aMatusch, A.$$b2$$uFZJ
000008020 7001_ $$0P:(DE-Juel1)138881$$aWu, B.$$b3$$uFZJ
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000008020 7001_ $$0P:(DE-Juel1)VDB1883$$aPalm, C.$$b5$$uFZJ
000008020 7001_ $$0P:(DE-HGF)0$$aBecker, J. S.$$b6
000008020 773__ $$0PERI:(DE-600)1491946-1$$a10.1002/mas.20239$$gp. 156 - 175$$p156 - 175$$q156 - 175$$tMass spectrometry reviews$$x0277-7037$$y2010
000008020 8567_ $$uhttp://dx.doi.org/10.1002/mas.20239
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