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@ARTICLE{Becker:8020,
      author       = {Becker, J. S. and Zoriy, M. and Matusch, A. and Wu, B. and
                      Salber, D. and Palm, C. and Becker, J. S.},
      title        = {{B}ioimaging of metals by laser ablation inductively
                      coupled plasma mass spectrometry ({LA}-{ICP}-{MS})},
      journal      = {Mass spectrometry reviews},
      volume       = {29},
      issn         = {0277-7037},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {PreJuSER-8020},
      pages        = {156 - 175},
      year         = {2010},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The distribution analysis of (essential, beneficial, or
                      toxic) metals (e.g., Cu, Fe, Zn, Pb, and others),
                      metalloids, and non-metals in biological tissues is of key
                      interest in life science. Over the past few years, the
                      development and application of several imaging mass
                      spectrometric techniques has been rapidly growing in biology
                      and medicine. Especially, in brain research metalloproteins
                      are in the focus of targeted therapy approaches of
                      neurodegenerative diseases such as Alzheimer's and
                      Parkinson's disease, or stroke, or tumor growth. Laser
                      ablation inductively coupled plasma mass spectrometry
                      (LA-ICP-MS) using double-focusing sector field (LA-ICP-SFMS)
                      or quadrupole-based mass spectrometers (LA-ICP-QMS) has been
                      successfully applied as a powerful imaging (mapping)
                      technique to produce quantitative images of detailed
                      regionally specific element distributions in thin tissue
                      sections of human or rodent brain. Imaging LA-ICP-QMS was
                      also applied to investigate metal distributions in plant and
                      animal sections to study, for example, the uptake and
                      transport of nutrient and toxic elements or environmental
                      contamination. The combination of imaging LA-ICP-MS of
                      metals with proteomic studies using biomolecular mass
                      spectrometry identifies metal-containing proteins and also
                      phosphoproteins. Metal-containing proteins were imaged in a
                      two-dimensional gel after electrophoretic separation of
                      proteins (SDS or Blue Native PAGE). Recent progress in
                      LA-ICP-MS imaging as a stand-alone technique and in
                      combination with MALDI/ESI-MS for selected life science
                      applications is summarized.},
      keywords     = {Animals / Brain Chemistry / Equipment Design / Humans /
                      Laser Therapy: instrumentation / Laser Therapy: methods /
                      Laser Therapy: trends / Mass Spectrometry: instrumentation /
                      Mass Spectrometry: methods / Mass Spectrometry: trends /
                      Metals: analysis / Neurodegenerative Diseases: pathology /
                      Plants: chemistry / Metals (NLM Chemicals) / J (WoSType)},
      cin          = {INM-2 / INM-4 / INM-1 / ZCH / S},
      ddc          = {530},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)ZCH-20090406 /
                      I:(DE-Juel1)VDB224},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      Nukleare Sicherheitsforschung (FUEK404) / 89571 -
                      Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)FUEK404 /
                      G:(DE-HGF)POF2-89571},
      shelfmark    = {Spectroscopy},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19557838},
      UT           = {WOS:000273518300007},
      doi          = {10.1002/mas.20239},
      url          = {https://juser.fz-juelich.de/record/8020},
}