Hauptseite > Publikationsdatenbank > Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) > print

001     8020
005     20210129210439.0
024 7 _ |2 pmid
|a pmid:19557838
024 7 _ |2 DOI
|a 10.1002/mas.20239
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|a WOS:000273518300007
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037 _ _ |a PreJuSER-8020
041 _ _ |a eng
082 _ _ |a 530
084 _ _ |2 WoS
|a Spectroscopy
100 1 _ |a Becker, J. S.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB2662
245 _ _ |a Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
260 _ _ |a New York, NY [u.a.]
|b Wiley
|c 2010
300 _ _ |a 156 - 175
336 7 _ |a Journal Article
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|2 PUB:(DE-HGF)
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a article
|2 DRIVER
440 _ 0 |a Mass Spectrometry Reviews
|x 0277-7037
|0 21761
|y 1
|v 29
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a The distribution analysis of (essential, beneficial, or toxic) metals (e.g., Cu, Fe, Zn, Pb, and others), metalloids, and non-metals in biological tissues is of key interest in life science. Over the past few years, the development and application of several imaging mass spectrometric techniques has been rapidly growing in biology and medicine. Especially, in brain research metalloproteins are in the focus of targeted therapy approaches of neurodegenerative diseases such as Alzheimer's and Parkinson's disease, or stroke, or tumor growth. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) using double-focusing sector field (LA-ICP-SFMS) or quadrupole-based mass spectrometers (LA-ICP-QMS) has been successfully applied as a powerful imaging (mapping) technique to produce quantitative images of detailed regionally specific element distributions in thin tissue sections of human or rodent brain. Imaging LA-ICP-QMS was also applied to investigate metal distributions in plant and animal sections to study, for example, the uptake and transport of nutrient and toxic elements or environmental contamination. The combination of imaging LA-ICP-MS of metals with proteomic studies using biomolecular mass spectrometry identifies metal-containing proteins and also phosphoproteins. Metal-containing proteins were imaged in a two-dimensional gel after electrophoretic separation of proteins (SDS or Blue Native PAGE). Recent progress in LA-ICP-MS imaging as a stand-alone technique and in combination with MALDI/ESI-MS for selected life science applications is summarized.
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650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Brain Chemistry
650 _ 2 |2 MeSH
|a Equipment Design
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Laser Therapy: instrumentation
650 _ 2 |2 MeSH
|a Laser Therapy: methods
650 _ 2 |2 MeSH
|a Laser Therapy: trends
650 _ 2 |2 MeSH
|a Mass Spectrometry: instrumentation
650 _ 2 |2 MeSH
|a Mass Spectrometry: methods
650 _ 2 |2 MeSH
|a Mass Spectrometry: trends
650 _ 2 |2 MeSH
|a Metals: analysis
650 _ 2 |2 MeSH
|a Neurodegenerative Diseases: pathology
650 _ 2 |2 MeSH
|a Plants: chemistry
650 _ 7 |0 0
|2 NLM Chemicals
|a Metals
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a bioimaging of metals
653 2 0 |2 Author
|a laser ablation inductively coupled plasma mass spectrometry
653 2 0 |2 Author
|a metal distribution
653 2 0 |2 Author
|a metal-lomics
653 2 0 |2 Author
|a neurodegenerative diseases
700 1 _ |a Zoriy, M.
|b 1
|u FZJ
|0 P:(DE-Juel1)VDB25017
700 1 _ |a Matusch, A.
|b 2
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|0 P:(DE-Juel1)138474
700 1 _ |a Wu, B.
|b 3
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|0 P:(DE-Juel1)138881
700 1 _ |a Salber, D.
|b 4
|u FZJ
|0 P:(DE-Juel1)VDB64651
700 1 _ |a Palm, C.
|b 5
|u FZJ
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700 1 _ |a Becker, J. S.
|b 6
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773 _ _ |a 10.1002/mas.20239
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|t Mass spectrometry reviews
|y 2010
|x 0277-7037
856 7 _ |u http://dx.doi.org/10.1002/mas.20239
909 C O |o oai:juser.fz-juelich.de:8020
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