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000807750 1001_ $$0P:(DE-HGF)0$$aVolz, L. J.$$b0
000807750 245__ $$aShaping Early Reorganization of Neural Networks Promotes Motor Function after Stroke.
000807750 260__ $$aOxford$$bOxford Univ. Press$$c2016
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000807750 520__ $$aNeural plasticity is a major factor driving cortical reorganization after stroke. We here tested whether repetitively enhancing motor cortex plasticity by means of intermittent theta-burst stimulation (iTBS) prior to physiotherapy might promote recovery of function early after stroke. Functional magnetic resonance imaging (fMRI) was used to elucidate underlying neural mechanisms. Twenty-six hospitalized, first-ever stroke patients (time since stroke: 1-16 days) with hand motor deficits were enrolled in a sham-controlled design and pseudo-randomized into 2 groups. iTBS was administered prior to physiotherapy on 5 consecutive days either over ipsilesional primary motor cortex (M1-stimulation group) or parieto-occipital vertex (control-stimulation group). Hand motor function, cortical excitability, and resting-state fMRI were assessed 1 day prior to the first stimulation and 1 day after the last stimulation. Recovery of grip strength was significantly stronger in the M1-stimulation compared to the control-stimulation group. Higher levels of motor network connectivity were associated with better motor outcome. Consistently, control-stimulated patients featured a decrease in intra- and interhemispheric connectivity of the motor network, which was absent in the M1-stimulation group. Hence, adding iTBS to prime physiotherapy in recovering stroke patients seems to interfere with motor network degradation, possibly reflecting alleviation of post-stroke diaschisis.
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000807750 7001_ $$0P:(DE-HGF)0$$aRehme, A. K.$$b1
000807750 7001_ $$0P:(DE-HGF)0$$aMichely, J.$$b2
000807750 7001_ $$0P:(DE-Juel1)165785$$aNettekoven, C.$$b3
000807750 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b4$$ufzj
000807750 7001_ $$0P:(DE-Juel1)131720$$aFink, G. R.$$b5$$ufzj
000807750 7001_ $$0P:(DE-Juel1)161406$$aGrefkes, Christian$$b6$$eCorresponding author$$ufzj
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