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@ARTICLE{Fink:807841,
      author       = {Fink, Gereon R. and Grefkes, Christian and Weiss, Peter H.},
      title        = {{N}ew hope for ameliorating stroke-induced deficits?},
      journal      = {Brain},
      volume       = {139},
      number       = {4},
      issn         = {1460-2156},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2016-02201},
      pages        = {1002 - 1004},
      year         = {2016},
      abstract     = {This scientific commentary refers to ‘Electrical
                      stimulation of the motor cortex enhances treatment outcome
                      in post-stroke aphasia’ by Meinzer et al.
                      (doi:10.1093/brain/aww002).The overall decline in stroke
                      mortality observed over the past decades is due to both a
                      reduction in stroke incidence, primarily resulting from
                      cardiovascular risk factor interventions, and substantial
                      progress in the acute treatment of stroke (e.g.
                      recanalization due to thrombolysis and thrombectomy,
                      decompressive therapy) as well as patient care (stroke
                      units) (Mozaffarian et al., 2016). These improvements (in
                      particular among people older than 65 years) are mirrored,
                      however, by an increasing number of stroke survivors, who
                      are left with persistent neurological deficits. Despite
                      intensive rehabilitation, at least in countries with well
                      developed healthcare systems, many stroke survivors are left
                      with motor, language, spatial or other neuropsychological
                      sequelae, all of which result in reduced functional
                      independence. Consequently, stroke is the leading cause of
                      acquired long-term disability and globally produces immense
                      health, social and economic burdens (Mozaffarian et al.,
                      2016). While physiotherapy, language therapy and
                      occupational therapy are widely accepted elements of
                      rehabilitation medicine that aim to restore functioning and
                      quality of life in those with physical disabilities or
                      cognitive impairments, novel approaches to rehabilitation
                      are urgently needed. Such therapies may comprise
                      behavioural, pharmacological or technical approaches, the
                      latter including the use of robotic devices as well as
                      non-invasive neuromodulatory techniques [i.e. transcranial
                      magnetic stimulation (TMS) or transcranial direct current
                      stimulation (tDCS)]. In this issue of Brain, Meinzer and
                      colleagues raise new hope for the treatment of post-stroke
                      aphasia by showing that electrical stimulation of the motor
                      cortex [sic!] enhances treatment outcomes (Meinzer et al.,
                      2016).},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000374234900009},
      pubmed       = {pmid:27012489},
      doi          = {10.1093/brain/aww034},
      url          = {https://juser.fz-juelich.de/record/807841},
}