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@ARTICLE{ZhangHaagen:808413,
      author       = {Zhang-Haagen, Bo and Biehl, Ralf and Nagel-Steger, Luitgard
                      and Radulescu, Aurel and Richter, Dieter and Willbold,
                      Dieter},
      title        = {{M}onomeric {A}myloid {B}eta {P}eptide in
                      {H}exafluoroisopropanol {D}etected by {S}mall {A}ngle
                      {N}eutron {S}cattering},
      journal      = {PLoS one},
      volume       = {11},
      number       = {2},
      issn         = {1932-6203},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {FZJ-2016-02236},
      pages        = {e0150267 -},
      year         = {2016},
      abstract     = {Small proteins like amyloid beta (Aβ) monomers are related
                      to neurodegenerative disorders by aggregation to insoluble
                      fibrils. Small angle neutron scattering (SANS) is a
                      nondestructive method to observe the aggregation process in
                      solution. We show that SANS is able to resolve monomers of
                      small molecular weight like Aβ for aggregation studies. We
                      examine Aβ monomers after prolonged storing in
                      d-hexafluoroisopropanol (dHFIP) by using SANS and dynamic
                      light scattering (DLS). We determined the radius of gyration
                      from SANS as 1.0±0.1 nm for Aβ1–40 and 1.6±0.1 nm for
                      Aβ1–42 in agreement with 3D NMR structures in similar
                      solvents suggesting a solvent surface layer with $5\%$
                      increased density. After initial dissolution in dHFIP Aβ
                      aggregates sediment with a major component of pure monomers
                      showing a hydrodynamic radius of 1.8±0.3 nm for Aβ1–40
                      and 3.2±0.4 nm for Aβ1–42 including a surface layer of
                      dHFIP solvent molecules.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1 /
                      ICS-1 / ICS-6},
      ddc          = {500},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)ICS-1-20110106 /
                      I:(DE-Juel1)ICS-6-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 553 - Physical Basis of
                      Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-553},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000371274400114},
      pubmed       = {pmid:26919121},
      doi          = {10.1371/journal.pone.0150267},
      url          = {https://juser.fz-juelich.de/record/808413},
}