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@ARTICLE{Fahlke:808781,
      author       = {Fahlke, Christoph and Kortzak, Daniel and Machtens,
                      Jan-Philipp},
      title        = {{M}olecular physiology of {EAAT} anion channels},
      journal      = {Pflügers Archiv},
      volume       = {468},
      number       = {3},
      issn         = {1432-2013},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2016-02397},
      pages        = {491 - 502},
      year         = {2016},
      abstract     = {Glutamate is the major excitatory neurotransmitter in the
                      mammalian central nervous system. After release from
                      presynaptic nerve terminals, glutamate is quickly removed
                      from the synaptic cleft by a family of five glutamate
                      transporters, the so-called excitatory amino acid
                      transporters (EAAT1–5). EAATs are prototypic members of
                      the growing number of dual-function transport proteins: they
                      are not only glutamate transporters, but also anion
                      channels. Whereas the mechanisms underlying secondary active
                      glutamate transport are well understood at the functional
                      and at the structural level, mechanisms and cellular roles
                      of EAAT anion conduction have remained elusive for many
                      years. Recently, molecular dynamics simulations combined
                      with simulation-guided mutagenesis and experimental analysis
                      identified a novel anion-conducting conformation, which
                      accounts for all experimental data on EAAT anion currents
                      reported so far. We here review recent findings on how EAATs
                      accommodate a transporter and a channel in one single
                      protein.},
      cin          = {ICS-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000370177200010},
      pubmed       = {pmid:26687113},
      doi          = {10.1007/s00424-015-1768-3},
      url          = {https://juser.fz-juelich.de/record/808781},
}