% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Stegmayr:810069,
      author       = {Stegmayr, Carina and Schöneck, Michael and Oliveira,
                      Dennis and Willuweit, Antje and Filss, Christian and
                      Galldiks, Norbert and Shah, N. J. and Coenen, Heinrich
                      Hubert and Langen, Karl-Josef},
      title        = {{R}eproducibility of
                      {O}-(2-$^{18}${F}-fluoroethyl)-{L}-tyrosine uptake kinetics
                      in brain tumors and influence of corticoid therapy: an
                      experimental study in rat gliomas},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {43},
      number       = {6},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2016-02950},
      pages        = {1115 - 1123},
      year         = {2016},
      abstract     = {PurposePositron emission tomography (PET) using
                      O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) is a
                      well-established method for the diagnostics of brain tumors.
                      This study investigates reproducibility of 18F-FET uptake
                      kinetics in rat gliomas and the influence of the frequently
                      used dexamethasone (Dex) therapy.MethodsF98 glioma or 9L
                      gliosarcoma cells were implanted into the striatum of 31
                      Fischer rats. After 10–11 days of tumor growth, the
                      animals underwent dynamic PET after injection of 18F-FET
                      (baseline). Thereafter, animals were divided into a control
                      group and a group receiving Dex injections, and all animals
                      were reinvestigated 2 days later. Tumor-to-brain ratios
                      (TBR) of 18F-FET uptake (18–61 min p.i.) and the slope of
                      the time-activity-curves (TAC) (18–61 min p.i.) were
                      evaluated using a Volume-of-Interest (VOI) analysis. Data
                      were analyzed by two-way repeated measures ANOVA and
                      reproducibility by the intraclass correlation coefficient
                      (ICC).ResultsThe slope of the tumor TACs showed high
                      reproducibility with an ICC of 0.93. A systematic increase
                      of the TBR in the repeated scans was noted (3.7 ± 2.8
                      $\%;$ p < 0.01), and appeared to be related to tumor
                      growth as indicated by a significant correlation of TBR and
                      tumor volume (r = 0.77; p < 0.0001). After
                      correction for tumor growth TBR showed high longitudinal
                      stability with an ICC of 0.84. Dex treatment induced a
                      significant decrease of the TBR (−8.2 ± 6.1 $\%;$
                      p < 0.03), but did not influence the slope of the tumor
                      TAC.ConclusionTBR of 18F-FET uptake and tracer kinetics in
                      brain tumors showed high longitudinal stability. Dex therapy
                      may induce a minor decrease of the TBR; this needs further
                      investigation.},
      cin          = {INM-4 / INM-5 / JARA-BRAIN / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-5-20090406 /
                      $I:(DE-82)080010_20140620$ / I:(DE-Juel1)INM-3-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000374972900016},
      doi          = {10.1007/s00259-015-3274-4},
      url          = {https://juser.fz-juelich.de/record/810069},
}