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@ARTICLE{Kebir:810072,
      author       = {Kebir, S. and Fimmers, R. and Galldiks, N. and Scha fer,
                      N. and Mack, F. and Schaub, C. and Stuplich, M. and Niessen,
                      M. and Tzaridis, T. and Simon, M. and Stoffels, G. and
                      Langen, K.-J. and Scheffler, B. and Glas, M. and Herrlinger,
                      U.},
      title        = {{L}ate {P}seudoprogression in {G}lioblastoma: {D}iagnostic
                      {V}alue of {D}ynamic
                      {O}-(2-[$^{18}${F}]fluoroethyl)-{L}-{T}yrosine {PET}},
      journal      = {Clinical cancer research},
      volume       = {22},
      number       = {9},
      issn         = {1557-3265},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {AACR},
      reportid     = {FZJ-2016-02953},
      pages        = {2190 - 2196},
      year         = {2016},
      abstract     = {Purpose: Pseudoprogression (PsP) is characterized by
                      therapy-associated but not tumor growth–associated
                      increases of contrast-enhancing glioblastoma lesions on MRI.
                      Although typically occurring during the first 3 months after
                      radiochemotherapy, PsP may occur later in the course of the
                      disease and may then be particularly difficult to
                      distinguish from true tumor progression. We explored PET
                      using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET-PET) to
                      approach the diagnostic dilemma.Experimental Design:
                      Twenty-six patients with glioblastoma that presented with
                      increasing contrast-enhancing lesions later than 3 months
                      after completion of radiochemotherapy underwent
                      18F-FET–PET. Maximum and mean tumor/brain ratios (TBRmax
                      and TBRmean) of 18F-FET uptake as well as time-to-peak (TTP)
                      and patterns of the time-activity curves were determined.
                      The final diagnosis of true progression versus late PsP was
                      based on follow-up MRI using RANO criteria.Results: Late PsP
                      occurred in 7 patients with a median time from
                      radiochemotherapy completion of 24 weeks while the remaining
                      patients showed true tumor progression. TBRmax and TBRmean
                      were significantly higher in patients with true progression
                      than in patients with late PsP (TBRmax 2.4 ± 0.1 vs. 1.5 ±
                      0.2, P = 0.003; TBRmean 2.1 ± 0.1 vs. 1.5 ± 0.2, P =
                      0.012) whereas TTP was significantly shorter (mean TTP 25 ±
                      2 vs. 40 ± 2 min, P < 0.001). ROC analysis yielded an
                      optimal cutoff value of 1.9 for TBRmax to differentiate
                      between true progression and late PsP (sensitivity $84\%,$
                      specificity $86\%,$ accuracy $85\%,$ P = 0.015).Conclusions:
                      O-(2-[18F]fluoroethyl)-L-tyrosine PET provides valuable
                      information in assessing the elusive phenomenon of late PsP.
                      Clin Cancer Res; 22(9); 2190–6. ©2015 AACR.},
      cin          = {INM-3 / INM-4 / IKP-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)IKP-4-20111104 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000375329100015},
      pubmed       = {pmid:26673798},
      doi          = {10.1158/1078-0432.CCR-15-1334},
      url          = {https://juser.fz-juelich.de/record/810072},
}